TEST:

Immunoscore® TCE test

"Veracyte...announced today that three abstracts highlighting the company’s unique, multi-omics immuno-oncology capabilities and offerings will be presented at the Society for Immunotherapy of Cancer’s 37th Annual Meeting & Pre-Conference Programs (SITC 2022), taking place November 8-12, 2022, in Boston."

Interestingly, in the 17 “Cold tumors”, high infiltration of PMN-MDSC and granulocytes also identified 5 patients with worse prognostic: at 2.5 months, only 20% PFS vs 58% in the low-density group (NS) (table 1). Conclusions Brightplex® TCE and MDSC assays in combination allowed the stratification of advanced NSCLC patients in 5 subgroups, among which two subgroups with poor outcome and no responder, representing 45% of the total population that would likely not benefit from anti-PD1/L1 monotherapy.

N=450; PIONeeR (NCT03493581); “The posters include new data regarding the use of Brightplex TCE (for T Cells Exhaustion) to stratify non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors in the ‘Biomarker analysis’ part of the PIONeeR project….New findings on a preliminary PIONeeR patient data set suggest that one of those tests, the Brightplex TCE assay, can stratify NSCLC patients eligible for anti-PD-1/PD-L1 therapy into four Spatial Tumor-infiltrating lymphocyte (TILs)….In the Hot subtype, for example, long-term progression-free survival (PFS) is observed for more than 40% of patients, regardless of PD-L1 status. In this Hot subtype, activated T-cell densities seem higher in tumors of patients with longer PFS, suggesting that immune-response evaluation with the Brightplex TCE assay could refine the stratification of patients, enriching responders to immune checkpoint inhibitor therapy.”

"Veracyte...announced that three abstracts highlighting the company’s immuno-oncology offerings for biopharmaceutical researchers will be presented at the Society for Immunotherapy of Cancer's (SITC) 36th Annual Meeting, taking place in Washington, DC and virtually, November 10-14, 2021...Poster Title: 'Spatial distribution of infiltrating T lymphocytes with Immunoscore® CR T Cells Exhaustion test helps stratification of NSCLC patients treated with PD1/L1 inhibitors in the PIONeeR project'."

Methods Advanced NSCLC pts with available archived tumor tissue at screening visit (VS), treated with standard PD1/L1 ICIs (nivolumab, pembrolizumab or atezolizumab), alone (2nd line or more) or combined with chemotherapy (1st line), were re-biopsied at 6 weeks (V2) of treatment. Additional tests performed on the PIONeeR cohort to explore other aspects of the immune response to cancer should complete these results. Trial Registration NCT03493581