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our Premium Content: News alerts, weekly reports and conference plannersTEST:CNV+ Breast Cancer NGS Panel
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News alerts, weekly reports and conference planners
Company:
NuProbeType:
Laboratory Developed Test
Related tests:
The CNV+ Breast Cancer NGS Panel covers 84 frequently mutated cancer hotspots in 14 genes and CNVs of HER2, amplified in 10-20% of breast cancers and guide treatment with trastuzumab (HERCEPTIN). It utilizes unique molecular identifiers(UMI) and PCR to accurately quantify SNVs and Indels down to 0.2% VAF as well as detect CNVs in HER2 above 2.04 copies and below 1.97 copies from cfDNA.
Cancer:
Breast Cancer
Gene:
AKT1 (V-akt murine thymoma viral oncogene homolog 1), AKT3 (V-akt murine thymoma viral oncogene homolog 3), AR (Androgen receptor), BRAF (B-raf proto-oncogene), BRCA1 (Breast cancer 1, early onset), BRCA2 (Breast cancer 2, early onset)
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AKT1 (V-akt murine thymoma viral oncogene homolog 1), AKT3 (V-akt murine thymoma viral oncogene homolog 3), AR (Androgen receptor), BRAF (B-raf proto-oncogene), BRCA1 (Breast cancer 1, early onset), BRCA2 (Breast cancer 2, early onset), BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1), EGFR (Epidermal growth factor receptor), ER (Estrogen receptor), ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3), ERBB4 (erb-b2 receptor tyrosine kinase 4), FGFR1 (Fibroblast growth factor receptor 1), HER-2 (Human epidermal growth factor receptor 2), KRAS (KRAS proto-oncogene GTPase), MYC (V-myc avian myelocytomatosis viral oncogene homolog), PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), PTEN (Phosphatase and tensin homolog), PTGS2 (Prostaglandin-Endoperoxide Synthase 2), RAD51C (RAD51 paralog C), TP53 (Tumor protein P53)
Drug:
Herceptin (trastuzumab)
Method:
Next-Generation Sequencing (NGS)
