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    DRUG:

    SB02024

    i
    Other names: SB02024, Vps34
    Company:
    Ono Pharma, Sprint Bioscience
    Drug class:
    PI3K inhibitor
    Related drugs:
    7ms
    Unleashing anti-tumor immunity: Targeting the autophagy-related protein VPS34 to enhance STING agonist-based therapy. (PubMed, Autophagy Rep)
    In vivo, treatment with the VPS34 inhibitor SB02024 enhances the positive effects of the STING agonist ADU-S100 in melanoma tumor-bearing mice. Thus, our study suggests that VPS34 inhibitors could be used to enhance STING-based anticancer therapies. CCL5 (C-C motif chemokine 5); CXCL10 (C-X-C motif chemokine 10); IFN (interferon); VPS34 (vacuolar protein sorting 34); cGAS (cyclic GMP-AMP Synthase); STING (stimulator of interferon genes protein); cGAMP (2'3'-cyclic guanosine monophosphate-adenosine monophosphate).
    Journal • IO biomarker
    |
    CXCL10 (Chemokine (C-X-C motif) ligand 10) • STING (stimulator of interferon response cGAMP interactor 1) • CCL5 (Chemokine (C-C motif) ligand 5) • CGAS (Cyclic GMP-AMP Synthase) • IFNB1 (Interferon Beta 1)
    |
    SB02024 • ADU-S100
    over1year
    Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy. (PubMed, Mol Oncol)
    These results show that VPS34 inhibition augments the cGAS/STING pathway, leading to greater tumor control through immune-mediated mechanisms. We propose that pharmacological VPS34 inhibition may synergize with emerging therapies targeting the cGAS/STING pathway.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CXCL10 (Chemokine (C-X-C motif) ligand 10) • STING (stimulator of interferon response cGAMP interactor 1) • CGAS (Cyclic GMP-AMP Synthase)
    |
    SB02024