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    DRUG:

    SB02024

    i
    Other names: SB02024, Vps34
    Company:
    Ono Pharma, Sprint Bioscience
    Drug class:
    PI3K inhibitor
    Related drugs:
    8ms
    Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy. (PubMed, Mol Oncol)
    These results show that VPS34 inhibition augments the cGAS/STING pathway, leading to greater tumor control through immune-mediated mechanisms. We propose that pharmacological VPS34 inhibition may synergize with emerging therapies targeting the cGAS/STING pathway.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CXCL10 (Chemokine (C-X-C motif) ligand 10) • STING (stimulator of interferon response cGAMP interactor 1) • CGAS (Cyclic GMP-AMP Synthase)
    |
    SB02024