Uveal Melanoma

We differentiated human pluripotent stem cells into the neuronal lineage and depleted BAP1 via doxycycline inducible shRNA...Bulk RNA seq analysis showed that neuronal progenitor and neural crest specific transcripts were reduced while surface ectoderm transcripts were higher in BAP1 depleted cells. Thus, our results clearly demonstrate that BAP1 is required for human neuronal progenitor cell formation, since it regulates neuronal and EMT genes.

P=N/A, N=50, Recruiting, Centre Jean Perrin | Active, not recruiting --> Recruiting | Trial completion date: Oct 2027 --> Apr 2028 | Trial primary completion date: Oct 2026 --> Apr 2028

TILs can be manufactured using the CliniMACS Prodigy. Administration of TIL via HAI was safe and feasible in patients with liver-dominant metastatic uveal melanoma. The used regimen appears insufficient to achieve durable clinical efficacy and implies a need for further testing to obtain conclusive results.

Analysis of microRNA expression levels in the blood plasma of CM patients can be used to assess the effectiveness of brachytherapy and to monitor patients within the framework of lifelong follow-up.

Photodynamic therapy is currently considered the preferred treatment in symptomatic cases.Choroidal metastases represent the most prevalent intraocular malignancies, with a primary origin in breast or lung carcinoma. Multimodal imaging is essential for diagnosis and monitoring, and management requires interdisciplinary coordination.A structured multimodal diagnostic approach is crucial for accurate classification, risk assessment, and individualized therapeutic planning in patients with choroidal tumors.

P2, N=378, Completed, Immunocore Ltd | Active, not recruiting --> Completed

P2, N=160, Active, not recruiting, IDEAYA Biosciences | Recruiting --> Active, not recruiting

P2, N=210, Active, not recruiting, Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026

These findings were replicated in vivo in a UM cell xenograft model. Taken together, UC2288 represents a promising candidate for further development that targets UM tumours with favourable anti-cancer effects.

P=N/A, N=10, Recruiting, Massachusetts General Hospital | Not yet recruiting --> Recruiting

Pairing these 3D models with co-culture techniques could dramatically improve the representativeness of UM models. Researchers should consider testing promising therapeutics on a panel of models representing different UM subtypes, with particular attention to high-risk UM, such as those with BAP1 loss.

She was diagnosed with uveal melanoma three months prior and was also in a 14-year remission from invasive ductal carcinoma. Investigations confirmed positive antinuclear antibodies (ANA) with PCNA (proliferating cell nuclear antigen) and myositis-specific antibodies including anti-Jo, anti-mitochondrial antibody (AMA-M2), and anti-benzylpenicilloyl antibody (BPO).