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DRUG:

UF-KURE19

i
Other names: UF-KURE19, UF-KURE19 CAR-T
Associations
Trials
Company:
Case Comprehensive Cancer Center
Drug class:
CD19-targeted CAR-T immunotherapy
Related drugs:
Associations
Trials
1year
Development and Clinical Validation of an Ultra-Fast CAR-T Manufacturing Platform Enabling Production of CAR-T Cells in Less Than 1 Day (ASH 2023)
The product passed all release criteria for infusion and was administered to the patient after lymphodepletion with fludarabine 30mg/m2 and cyclophosphamide 500mg/m2 daily for 3 days. UF-Kure19 cells expanded robustly in the patient and peaked around day 10 (23% of circulating CD3) with a strong skewing of CD4/CD8 cells (93% CD8+ T cells on day 10)...In vitro and animal data suggest this fast-manufacturing platform leads to potent CAR-T cells. Early human testing indicates CAR-T cells generated using this novel system have clinical activity against hematologic malignancies.
Clinical • CAR T-Cell Therapy • IO biomarker
|
CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
|
cyclophosphamide • fludarabine IV • UF-KURE19
over1year
Evaluate the Safety of UF-KURE19 Cells in Non-Hodgkin Lymphomas (clinicaltrials.gov)
P1, N=10, Recruiting, James Michael Martin | Trial completion date: Dec 2026 --> Dec 2024 | Initiation date: Oct 2023 --> Apr 2023 | Trial primary completion date: Jun 2026 --> Jun 2024
Trial completion date • Trial initiation date • Trial primary completion date
|
cyclophosphamide • fludarabine IV • UF-KURE19
almost2years
Evaluate the Safety of UF-KURE19 Cells in Non-Hodgkin Lymphomas (clinicaltrials.gov)
P1, N=10, Recruiting, James Michael Martin | Not yet recruiting --> Recruiting
Enrollment open
|
CD19 (CD19 Molecule)
|
CD19 positive
|
cyclophosphamide • fludarabine IV • UF-KURE19
over2years
New P1 trial
|
CD19 (CD19 Molecule)
|
CD19 positive
|
cyclophosphamide • fludarabine IV • UF-KURE19