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BIOMARKER:

TP53 exon 8 mutation

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Entrez ID:

Related biomarkers:

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TP53 mutation (312)

TP53 wild-type (46)

EGFR mutation + TP53 mutation (11)

BRCA1 2110_2111delAA + BRCA1 4071_4096 +14del40 + TP53 R342P + NOTCH2 Q1310H (7)

TP53 mutation + KRAS mutation (6)

ALK rearrangement + TP53 mutation (4)

KRAS G12C + TP53 mutation (3)

BRCA1 mutation + TP53 mutation (2)

BRCA2 mutation + TP53 mutation (2)

CDKN2A mutation + TP53 mutation (2)

EGFR L858R + TP53 mutation (2)

EGFR mutation + TP53 mutation + ARID1A mutation (2)

EGFR mutation + TP53 mutation + BRCA1 mutation (2)

EGFR mutation + TP53 mutation + NF1 mutation (2)

EGFR mutation + TP53 mutation + PTEN mutation (2)

EGFR mutation + TP53 mutation + RB1 mutation (2)

KRAS mutation + TP53 wild-type (2)

STK11 mutation + TP53 mutation (2)

TP53 T175H + PIK3CA H1047R (2)

TP53 mutation + PIK3CA mutation + CD74 mutation (2)

AHNAK2 mutation + TP53 mutation (1)

ALK rearrangement + ALK L1196M + TP53 mutation (1)

ALK rearrangement + ALK R1275Q + TP53 mutation (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

ALK rearrangement + TP53 wild-type (1)

ATRX mutation + TP53 mutation + PTEN mutation (1)

BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)

BRAF N486-P490del + TP53 V157G (1)

BRAF mutation + TP53 mutation (1)

BRCA1 mutation + TP53 R248Q (1)

BRCA2 Y1655* + TP53 mutation (1)

BRCA2 mutation + TP53 D816Y (1)

CXCR4 S338X + TP53 R196X (1)

DSPP mutation + TP53 mutation (1)

EGFR G719X + TP53 mutation (1)

EGFR L718V + TP53 V727M + EGFR L858R (1)

EGFR L858R + TP53 R273C + HER-2 S442L (1)

EGFR L858R + TP53 wild-type (1)

EGFR L861Q + TP53 mutation (1)

EGFR L861Q + TP53 mutation + RB1 mutation (1)

EGFR S768I + TP53 mutation (1)

EGFR T790M + TP53 R237C (1)

EGFR exon 19 deletion + TP53 exon 8 mutation (1)

EGFR exon 19 deletion + TP53 mutation (1)

EGFR exon 20 insertion + TP53 G244A + SPTA1 mutation (1)

EGFR mutation + BRAF mutation + TP53 mutation (1)

EGFR mutation + TP53 exon 6 mutation (1)

EGFR mutation + TP53 exon 7 mutation (1)

EGFR T790M + TP53 mutation (1)

HER-2 mutation + TP53 wild-type (1)

IDH1 mutation + TP53 mutation (1)

IDH2 mutation + TP53 mutation (1)

KMT2C mutation + TP53 mutation (1)

KRAS G12V + TP53 mutation + APC mutation (1)

KRAS mutation + STK11 mutation + TP53 mutation (1)

MET exon 14 mutation + TP53 mutation (1)

NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)

PTEN mutation + TP53 mutation (1)

RB1 mutation + TP53 mutation (1)

TERT mutation + TP53 mutation (1)

TP53 -181_-179delAAA (1)

TP53 G245S + ALK rearrangement (1)

TP53 R209fs* (1)

TP53 R333Vfs*12 (1)

TP53 exon 4 mutation (1)

TP53 exon 5 mutation (1)

TP53 mutation + ARID1A mutation (1)

TP53 mutation + ATM mutation (1)

TP53 mutation + BCL2 rearrangement (1)

TP53 mutation + CARD11 mutation + SMARCA4 mutation (1)

TP53 mutation + FGFR2 rearrangement (1)

TP53 mutation + IKZF1 mutation (1)

TP53 mutation + IKZF3 mutation (1)

TP53 mutation + MDM2 mutation (1)

TP53 mutation + NOTCH4 mutation (1)

TP53 mutation + NTRK3 mutation (1)

TP53 mutation + TSC2 mutation (1)

TP53 mutation + TTN mutation (1)

TP53 mutation + ZFHX3 mutation (1)

TP53 wild-type + LRP1B wild-type (1)

ALK mutation + TP53 mutation (0)

KRAS mutation + TP53 mutation (0)

NOTCH S2435S + TP53 G245A + TP53 P190T + TP53 FBXW7 + TP53 G477S (0)

TP53 Q16fs*28 (0)

TP53 exon 6 mutation (0)

TP53 exon 7 mutation (0)

TP53 mutation (312)

TP53 wild-type (46)

EGFR mutation + TP53 mutation (11)

BRCA1 2110_2111delAA + BRCA1 4071_4096 +14del40 + TP53 R342P + NOTCH2 Q1310H (7)

TP53 mutation + KRAS mutation (6)

ALK rearrangement + TP53 mutation (4)

KRAS G12C + TP53 mutation (3)

BRCA1 mutation + TP53 mutation (2)

BRCA2 mutation + TP53 mutation (2)

CDKN2A mutation + TP53 mutation (2)

EGFR L858R + TP53 mutation (2)

EGFR mutation + TP53 mutation + ARID1A mutation (2)

EGFR mutation + TP53 mutation + BRCA1 mutation (2)

EGFR mutation + TP53 mutation + NF1 mutation (2)

EGFR mutation + TP53 mutation + PTEN mutation (2)

EGFR mutation + TP53 mutation + RB1 mutation (2)

KRAS mutation + TP53 wild-type (2)

STK11 mutation + TP53 mutation (2)

TP53 T175H + PIK3CA H1047R (2)

TP53 mutation + PIK3CA mutation + CD74 mutation (2)

AHNAK2 mutation + TP53 mutation (1)

ALK rearrangement + ALK L1196M + TP53 mutation (1)

ALK rearrangement + ALK R1275Q + TP53 mutation (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

ALK rearrangement + TP53 wild-type (1)

ATRX mutation + TP53 mutation + PTEN mutation (1)

BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)

BRAF N486-P490del + TP53 V157G (1)

BRAF mutation + TP53 mutation (1)

BRCA1 mutation + TP53 R248Q (1)

BRCA2 Y1655* + TP53 mutation (1)

BRCA2 mutation + TP53 D816Y (1)

CXCR4 S338X + TP53 R196X (1)

DSPP mutation + TP53 mutation (1)

EGFR G719X + TP53 mutation (1)

EGFR L718V + TP53 V727M + EGFR L858R (1)

EGFR L858R + TP53 R273C + HER-2 S442L (1)

EGFR L858R + TP53 wild-type (1)

EGFR L861Q + TP53 mutation (1)

EGFR L861Q + TP53 mutation + RB1 mutation (1)

EGFR S768I + TP53 mutation (1)

EGFR T790M + TP53 R237C (1)

EGFR exon 19 deletion + TP53 exon 8 mutation (1)

EGFR exon 19 deletion + TP53 mutation (1)

EGFR exon 20 insertion + TP53 G244A + SPTA1 mutation (1)

EGFR mutation + BRAF mutation + TP53 mutation (1)

EGFR mutation + TP53 exon 6 mutation (1)

EGFR mutation + TP53 exon 7 mutation (1)

EGFR T790M + TP53 mutation (1)

HER-2 mutation + TP53 wild-type (1)

IDH1 mutation + TP53 mutation (1)

IDH2 mutation + TP53 mutation (1)

KMT2C mutation + TP53 mutation (1)

KRAS G12V + TP53 mutation + APC mutation (1)

KRAS mutation + STK11 mutation + TP53 mutation (1)

MET exon 14 mutation + TP53 mutation (1)

NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)

PTEN mutation + TP53 mutation (1)

RB1 mutation + TP53 mutation (1)

TERT mutation + TP53 mutation (1)

TP53 -181_-179delAAA (1)

TP53 G245S + ALK rearrangement (1)

TP53 R209fs* (1)

TP53 R333Vfs*12 (1)

TP53 exon 4 mutation (1)

TP53 exon 5 mutation (1)

TP53 mutation + ARID1A mutation (1)

TP53 mutation + ATM mutation (1)

TP53 mutation + BCL2 rearrangement (1)

TP53 mutation + CARD11 mutation + SMARCA4 mutation (1)

TP53 mutation + FGFR2 rearrangement (1)

TP53 mutation + IKZF1 mutation (1)

TP53 mutation + IKZF3 mutation (1)

TP53 mutation + MDM2 mutation (1)

TP53 mutation + NOTCH4 mutation (1)

TP53 mutation + NTRK3 mutation (1)

TP53 mutation + TSC2 mutation (1)

TP53 mutation + TTN mutation (1)

TP53 mutation + ZFHX3 mutation (1)

TP53 wild-type + LRP1B wild-type (1)

ALK mutation + TP53 mutation (0)

KRAS mutation + TP53 mutation (0)

NOTCH S2435S + TP53 G245A + TP53 P190T + TP53 FBXW7 + TP53 G477S (0)

TP53 Q16fs*28 (0)

TP53 exon 6 mutation (0)

TP53 exon 7 mutation (0)

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over3years

Prognostic Value of the TP53 Mutation Location in Metastatic Breast Cancer as Detected by Next-Generation Sequencing. (PubMed, Cancer Manag Res)

Of TP53-mutated patients, those with non-missense mutations in the DBD had worse breast cancer-related survival. TP53 mutations were also associated with endocrine resistance.

over 3 years ago

Journal • Next-generation sequencing

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HER-2 (Human epidermal growth factor receptor 2) • TP53 (Tumor protein P53)

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HER-2 positive • TP53 mutation • HR positive • HER-2 negative • HR positive + HER-2 negative • TP53 exon 8 mutation