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    BIOMARKER:

    TFG-ROS1 rearrangement

    i
    Other names: ROS1, ROS Proto-Oncogene 1 Receptor Tyrosine Kinase, V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1, C-Ros Oncogene 1 Receptor Tyrosine Kinase, Proto-Oncogene Tyrosine-Protein Kinase ROS, Proto-Oncogene C-Ros-1, MCF3, ROS, V-Ros UR2 Sarcoma Virus Oncogene Homolog 1 (Avian), ROS Proto-Oncogene 1 Receptor Tyrosine Kinase, Transmembrane Tyrosine-Specific Protein Kinase, Receptor Tyrosine Kinase C-Ros Oncogene 1, C-Ros Receptor Tyrosine Kinase, Proto-oncogene C-Ros, C-Ros-1, TFG, Trafficking
    Entrez ID:
    6098; 10342
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    7ms
    Reclassification of a spindle cell sarcoma after identification of a TFG-ROS1 fusion: A case demonstrating the clinical benefit of next-generation sequencing in sarcoma. (PubMed, Mol Genet Genomic Med)
    We discuss the role of NGS as well as its potential benefit in patients with unresectable, ALK-negative metastatic disease. Considering this case and previous literature, we support the use of NGS for patients requiring systemic treatment.
    Journal • Next-generation sequencing
    |
    ALK (Anaplastic lymphoma kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • CD34 (CD34 molecule) • SOX10 (SRY-Box 10) • USP6 (Ubiquitin Specific Peptidase 6)
    |
    ALK rearrangement • ALK fusion • ROS1 fusion • ROS1 rearrangement • ALK negative • TFG-ROS1 rearrangement
    |
    Xalkori (crizotinib)