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BIOMARKER:

ROS1 fusion

i
Other names: ROS Proto-Oncogene 1 Receptor Tyrosine Kinase, V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1, C-Ros Oncogene 1 Receptor Tyrosine Kinase, Proto-Oncogene Tyrosine-Protein Kinase ROS, Proto-Oncogene C-Ros-1, MCF3, ROS, V-Ros UR2 Sarcoma Virus Oncogene Homolog 1 (Avian), ROS Proto-Oncogene 1 Receptor Tyrosine Kinase, Transmembrane Tyrosine-Specific Protein Kinase, Receptor Tyrosine Kinase C-Ros Oncogene 1, C-Ros Receptor Tyrosine Kinase, Proto-oncogene C-Ros, C-Ros-1
Entrez ID:
ROS1 fusion
NSCLC
entrectinib
Sensitive: A1 - Approval
ROS1 fusion
NSCLC
crizotinib
Sensitive: A2 - Guideline
ROS1 fusion
Melanoma
entrectinib
Sensitive: A2 - Guideline
ROS1 fusion
Melanoma
crizotinib
Sensitive: A2 - Guideline
ROS1 fusion
NSCLC
TPX-0005
Sensitive: C2 – Inclusion Criteria
ROS1 fusion
NSCLC
AB106
Sensitive: C2 – Inclusion Criteria
ROS1 fusion
NSCLC
durvalumab
Resistant: C2 – Inclusion Criteria
ROS1 fusion
NSCLC
X-396
Sensitive: C3 – Early Trials
ROS1 fusion
NSCLC
crizotinib + bevacizumab
Sensitive: C4 – Case Studies
ROS1 fusion
GBM
lorlatinib
Sensitive: D – Preclinical
ROS1 fusion
Solid Tumor
SIM1803-1A
Sensitive: D – Preclinical