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BIOMARKER:

TFG-ROS1 rearrangement

i
Entrez ID:
11ms
Reclassification of a spindle cell sarcoma after identification of a TFG-ROS1 fusion: A case demonstrating the clinical benefit of next-generation sequencing in sarcoma. (PubMed, Mol Genet Genomic Med)
We discuss the role of NGS as well as its potential benefit in patients with unresectable, ALK-negative metastatic disease. Considering this case and previous literature, we support the use of NGS for patients requiring systemic treatment.
Journal • Next-generation sequencing
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ALK (Anaplastic lymphoma kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • CD34 (CD34 molecule) • SOX10 (SRY-Box 10) • USP6 (Ubiquitin Specific Peptidase 6)
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ALK rearrangement • ALK fusion • ROS1 fusion • ROS1 rearrangement • ALK negative • TFG-ROS1 rearrangement
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Xalkori (crizotinib)