Strong and persistent tumor regression in xenograft models of lymphoid malignancies in mouse and rat were observed at well tolerated doses following weekly IV administration of S65487 in combination with the MCL-1-specific inhibitor, S64315/MIK665. Altogether, these data demonstrate that S65487/VOB560 has significant therapeutic potential against human lymphoid and myeloid malignancies as well as in patients with Venetoclax resistant leukemias. Clinical studies are currently ongoing with S65487/VOB560 (NCT03755154).
3 years ago
Clinical • IO biomarker
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BCL2L1 (BCL2-like 1)
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BCL2 mutation • BCL2 G101V
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Venclexta (venetoclax) • Bcl-2 Family Inhibitors • MIK665 • S65487