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DRUG:

RF-1302

i
Other names: RF-1302, RF1302
Associations
Trials
Company:
Ruifu Therap
Drug class:
FLT3 inhibitor, PIM-1 inhibitor
Related drugs:
Associations
Trials
over1year
RF-1302, a novel dual inhibitor of PIM1 and FLT3 in preclinical treatment of acute myeloid leukemia (AACR 2023)
There are three FTL3 inhibitors, midostaurin, gilteritinib, and quizartinib have been approved for clinical treatment of AML. The treatment with RF-1302 showed very little toxicity (only 2% body weight loss) which were well below the maximum tolerated dose. These preclinical results suggest that RF-1302 represents a novel dual inhibitor of PIM1 and FLT3, which may constitute a highly efficacious modality for the treatment of FLT3 mutant AML, and is worthy of further clinical evaluation.
Preclinical
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FLT3 (Fms-related tyrosine kinase 3) • PIM1 (Pim-1 Proto-Oncogene)
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FLT3 mutation
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Xospata (gilteritinib) • Rydapt (midostaurin) • Vanflyta (quizartinib) • RF-1302