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    BIOMARKER:

    PDGFRA overexpression

    i
    Other names: Platelet Derived Growth Factor Receptor Alpha, Platelet-Derived Growth Factor Receptor Alpha Polypeptide, Alpha-Type Platelet-Derived Growth Factor Receptor, CD140 Antigen-Like Family Member A, CD140a Antigen, PDGF-R-Alpha, PDGFR-2, PDGFR2, Alpha Platelet-Derived Growth Factor Receptor, Platelet-Derived Growth Factor Alpha Receptor, PDGFR-Alpha, RHEPDGFRA, CD140A
    Entrez ID:
    5156
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    12ms
    AML with t(4; 12)(q12; p13): A Detailed Genomic and Transcriptomic Analysis Reveals Genomic Breakpoint Heterogeneity, Absence of Pdgfra Fusion Transcripts and Presence of Pdgfra Overexpression in a Subset of Cases (ASH 2023)
    Analysis of AML with t(4; 12)(q12; p13) translocation by WGS and WTS provides detailed information that separates two subsets distinguished by distinct breakpoint cluster regions on 4q12 and PDGFRA gene expression. The clinical impact of increased PDGFRA gene expression on response to TKI and prognosis as well as the presence of additional fusion transcripts has to be evaluated in further studies.
    Clinical • Omic analysis
    |
    BCR (BCR Activator Of RhoGEF And GTPase) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • ASXL1 (ASXL Transcriptional Regulator 1) • ETV6 (ETS Variant Transcription Factor 6) • ADAMTS3 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 3) • SCFD2 (Sec1 Family Domain Containing 2)
    |
    ASXL1 mutation • PDGFRA mutation • PDGFRA overexpression • PDGFRA fusion
    over1year
    Recurrent DNA Methylation Events Promote IDH-Mutant Gliomagenesis. (PubMed, Cancer Discov)
    Combining Pdgfra overexpression and Cdkn2a inhibition drives gliomagenesis in vivo.
    Journal • Epigenetic controller
    |
    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha)
    |
    CDKN2A overexpression • PDGFRA overexpression
    2years
    Platelet-derived growth factor signalling pathways in patient-derived glioblastoma cells (EANO 2022)
    Despite PDGF receptor expression, the GBM tumour cells, in contrast to pericytes, surprisingly displayed a lack of responses to ligand stimulation through either PDGFRα or PDGFRβ. This warrants further investigation into the signalling mechanisms behind tumour cells to better understand tumour biology.
    Clinical
    |
    PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • PDGFRB (Platelet Derived Growth Factor Receptor Beta)
    |
    PDGFRA expression • PDGFRA overexpression
    2years
    Co-amplified with PDGFRA, IGFBP7 is a prognostic biomarker correlated with the immune infiltrations of glioma. (PubMed, Cancer Med)
    IGFBP7 but not PDGFRA served an ideal prognostic marker and therapeutic target of glioma.
    Journal
    |
    PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • IGFBP7 (Insulin Like Growth Factor Binding Protein 7)
    |
    IDH wild-type • IGFBP7 overexpression • PDGFRA overexpression
    3years
    Prenatal overexpression of platelet-derived growth factor receptor A results in central nervous system hypomyelination. (PubMed, Brain Behav)
    Our results suggest that embryonic overexpression of hPDGFRA in Olig2- or GFAP-progenitors is deleterious to OPC development and leads to CNS hypomyelination.
    Journal
    |
    TP53 (Tumor protein P53) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • GFAP (Glial Fibrillary Acidic Protein)
    |
    PDGFRA overexpression