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    1m
    Anti-Inflammatory Oxysterol, Oxy210, Inhibits Atherosclerosis in Hyperlipidemic Mice and Inflammatory Responses of Vascular Cells. (PubMed, Cells)
    These findings suggest that Oxy210 could be a drug candidate for targeting both NASH and atherosclerosis, as well as chronic inflammation associated with the manifestations of metabolic syndrome.
    Preclinical • Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CCL2 (Chemokine (C-C motif) ligand 2) • APOE (Apolipoprotein E) • IL1B (Interleukin 1, beta) • VCAM1 (Vascular Cell Adhesion Molecule 1)
    |
    Oxy210
    over2years
    Oxysterol derivatives Oxy186 and Oxy210 inhibit WNT signaling in non-small cell lung cancer. (PubMed, Cell Biosci)
    The oxysterols Oxy186 and Oxy210 both possess inhibitory activity towards WNT/β-catenin signaling, and Oxy186 is also a potent inhibitor of NSCLC tumor growth.
    Journal
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    TGFB1 (Transforming Growth Factor Beta 1)
    |
    Oxy210