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    4ms
    Oxy210 Inhibits Hepatic Expression of Senescence-Associated, Pro-Fibrotic, and Pro-Inflammatory Genes in Mice During Development of MASH and in Hepatocytes In Vitro. (PubMed, Cells)
    These findings further support the potential therapeutic effects of Oxy210 mediated in part through inhibition of senescence-driven hepatic fibrosis and inflammation in MASH and perhaps in other senescence-associated fibrotic diseases.
    Preclinical • Journal
    |
    TGFB1 (Transforming Growth Factor Beta 1) • APOE (Apolipoprotein E)
    |
    Oxy210
    1year
    Anti-Inflammatory Oxysterol, Oxy210, Inhibits Atherosclerosis in Hyperlipidemic Mice and Inflammatory Responses of Vascular Cells. (PubMed, Cells)
    These findings suggest that Oxy210 could be a drug candidate for targeting both NASH and atherosclerosis, as well as chronic inflammation associated with the manifestations of metabolic syndrome.
    Preclinical • Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CCL2 (Chemokine (C-C motif) ligand 2) • APOE (Apolipoprotein E) • IL1B (Interleukin 1, beta) • VCAM1 (Vascular Cell Adhesion Molecule 1)
    |
    Oxy210
    over3years
    Oxysterol derivatives Oxy186 and Oxy210 inhibit WNT signaling in non-small cell lung cancer. (PubMed, Cell Biosci)
    The oxysterols Oxy186 and Oxy210 both possess inhibitory activity towards WNT/β-catenin signaling, and Oxy186 is also a potent inhibitor of NSCLC tumor growth.
    Journal
    |
    TGFB1 (Transforming Growth Factor Beta 1)
    |
    Oxy210