Osteosarcoma

This study provides the first mechanistic evidence that TNF-α regulates ADAMTS-2 expression through the coordinated activation of multiple signaling pathways and the engagement of STAT3 and NF-κB transcription factors at the promoter. These findings uncover a previously uncharacterized inflammatory regulatory axis linking TNF-α signaling to ECM remodeling and highlight ADAMTS-2 as a potential mediator of osteosarcoma progression.

LRRC15-CAR T cells exert anti-osteosarcoma activity while maintaining a positive safety profile. These promising findings support clinical translation of LRRC15-CAR T cells for patients with osteosarcoma and potentially other LRRC15-positive solid tumors.

This research uncovers a novel mechanism of SIRT1 in the genesis of nociceptive hypersensitivity in BCP and offers potential avenues for therapeutic intervention.

P=N/A, N=12, Not yet recruiting, The Clinical Technology Research And Development Center of Shanghai Proton and Heavy Ion Center; The Clinical Technology Research And Development Cent

P=N/A, N=67, Not yet recruiting, Shanghai Sixth People's Hospital; Shanghai Sixth People's Hospital

P=N/A, N=30000, Not yet recruiting, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

P=N/A, N=140, Completed, The Third Affiliated Hospital of Southern Medical University; The Third Affiliated Hospital of Southern Medical University

P=N/A, N=30, Not yet recruiting, Shanghai General Hospital; Shanghai General Hospital

P=N/A, N=101, Not yet recruiting, Shanghai Ninth People's Hospital， Shanghai JiaoTong University School of Medicine; Shanghai Ninth People's Hospital， Shanghai JiaoTong University

P2, N=65, Recruiting, Peking University People's Hospital; Shanghai AB PharmaTech Ltd. | Not yet recruiting --> Recruiting

The METTL3-IGF2BP3 axis facilitates OS progression by enhancing ID1 mRNA stability and expression, highlighting its potential as a therapeutic target.

In this study, we found that DLST promotes the proliferation, migration, invasion, anti-apoptosis of osteosarcoma cells, as well as tumor growth, regulated through the p38 MAPK signaling pathway. These results could offer novel and valuable perspectives for the clinical management of osteosarcoma.