Ocular Melanoma

Vision improved following four sessions of proton beam therapy. This case highlights the importance of multidisciplinary involvement, multimodal imaging, and gene expression profiling in facilitating early diagnosis and treatment.

This case underscores the clinical effectiveness and favorable tolerability of topical interferon alpha-2b in the management of recurrent ocular surface squamous neoplasia. The achievement of durable remission after a shortened treatment course highlights its potential as a flexible therapeutic option, with meaningful implications for clinical practice, particularly in settings with limited access to biologic therapies.

P2, N=12, Active, not recruiting, H. Lee Moffitt Cancer Center and Research Institute | N=37 --> 12 | Trial primary completion date: Dec 2026 --> Jul 2026 | Recruiting --> Active, not recruiting

A significant negative correlation between RiskScore and the IC50 of XMD8-85, lapatinib, roscovitine, salubrinal, bexarotene, LFM-A13, FTI-277, and TGX221 chemotherapeutic agents was further noticed. In this study, we computationally identified genes associated with both disease progression and macrophage/monocyte-related characteristics in UVM and constructed a prognostic risk model with predicted immune infiltration patterns. These findings generate testable hypotheses that may inform future experimental studies on the immune mechanisms underlying UVM.

These analyses revealed that AMF directly targets smoothened (SMO) to disrupt the SHh signaling pathway, thereby suppressing RB stem cell (RBSC) self-renewal and tumor progression. This work uncovers a previously unreported mechanism by which AMF hinders RB development and highlights its potential as a promising therapeutic candidate for this aggressive pediatric cancer.

This case illustrates a rare late local recurrence of choroidal melanoma with different appearance from the original tumor. It also highlights the diagnostic and prognostic role of transretinal biopsy in confirming the nature of the lesion as a recurrence and the option of proton beam radiation as salvage therapy.

Serum levels of CEA and CA19-9 normalized one month postoperatively, and no recurrence has been observed during follow-up. When a multilocular cystic mass with cyst-in-cyst morphology and a stained glass-like appearance is identified in the liver-even in the absence of definite malignant imaging features-MCN should be considered, including in cases arising in the right hepatic lobe.

Understanding the underlying mechanisms involved in RB and exploring new treatment strategies is a crucial step toward developing more effective and less invasive therapeutic approaches that can improve patient outcomes. This review summarizes the significant genetic and epigenetic alterations involved in RB tumorigenesis, current therapeutic strategies, and future treatment prospects for patients with RB.

P=N/A, N=32, Terminated, Centre Antoine Lacassagne | Phase classification: P2 --> P=N/A

Analogous PAX3 positive populations were also identified in mouse and human single-cell transcriptomic datasets. Collectively, these findings establish a critical role for Mitfa-independent melanocyte progenitors in UM pathogenesis.

A high frequency of NA and the Klippel-Trénaunay phenotype (or leg-length discrepancy) was observed in phacomatosis melanocesioflammea. The existence of "pseudodidymosis cesioanemica" is also corroborated.