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DRUG:

NanoPac (paclitaxel nanoformulation)

i
Other names: LSAM-PTX, LSAM paclitaxel
Associations
Company:
NanOlogy
Drug class:
Bcl2 inhibitor, Tubulin inhibitor
Related drugs:
Associations
5ms
Trial of NanoPac® in Subjects With Locally Advanced Pancreatic Adenocarcinoma (clinicaltrials.gov)
P2, N=54, Completed, NanOlogy, LLC | Phase classification: P2a --> P2
Phase classification • Metastases
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NanoPac (paclitaxel nanoformulation)
10ms
Intratumoral Treatment of Melanoma Tumors with Large Surface Area Microparticle Paclitaxel and Synergy with Immune Checkpoint Inhibition. (PubMed, Int J Nanomedicine)
Increases in natural killer (NK) cells were found in lymph node tissue in the combination treatment group. These findings suggest that IT LSAM-PTX may provide benefit in the local treatment of melanomas and may synergize with systemic anti-PD-1 therapy, leading to additional tumoricidal outcomes without added systemic toxicity.
Journal • Checkpoint inhibition
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CD4 (CD4 Molecule)
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NanoPac (paclitaxel nanoformulation)
1year
Trial of NanoPac Intratumoral Injection in Lung Cancer (clinicaltrials.gov)
P2, N=18, Completed, NanOlogy, LLC | Active, not recruiting --> Completed | Trial completion date: Feb 2024 --> Sep 2023
Trial completion • Trial completion date
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NanoPac (paclitaxel nanoformulation)
1year
Trial of NanoPac® in Subjects With Locally Advanced Pancreatic Adenocarcinoma (clinicaltrials.gov)
P2a, N=54, Completed, NanOlogy, LLC | Active, not recruiting --> Completed
Trial completion • Metastases
|
paclitaxel • NanoPac (paclitaxel nanoformulation)
over4years
Intracystic Injection of NanoPac® in Subjects With Mucinous Cystic Pancreatic Neoplasms (clinicaltrials.gov)
P2, N=30, Active, not recruiting, NanOlogy, LLC | Recruiting --> Active, not recruiting | Trial completion date: Dec 2019 --> Jul 2020 | Trial primary completion date: Dec 2019 --> Jul 2020
Clinical • Enrollment closed • Trial completion date • Trial primary completion date
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KRAS (KRAS proto-oncogene GTPase) • CEACAM5 (CEA Cell Adhesion Molecule 5)
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NanoPac (paclitaxel nanoformulation)
almost5years
Nanotechnology, in silico and endocrine-based strategy for delivering paclitaxel and miRNA: Prospects for the therapeutic management of breast cancer. (PubMed, Semin Cancer Biol)
miRNA delivery to a specific target site, the development of paclitaxel and miRNA formulations, and nanotechnological strategies for the delivery of nanopaclitaxel in the management of breast cancer are discussed...An in silico analysis revealed that ANG1005 and Abraxane nanoformulations have superior and significantly enhanced interactions with the proteins α-tubulin and Bcl-2...miRNAs can revert abnormal gene expression to normalcy; since miRNAs serve as tumor suppressors. Therefore, restoration of particular miRNAs levels as a replacement therapy may be an effective endocrine potential strategy for treating ER positive/ negative breast cancers.
Review • Journal
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BCL2 (B-cell CLL/lymphoma 2)
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albumin-bound paclitaxel • NanoPac (paclitaxel nanoformulation) • paclitaxel trevatide (ANG1005)