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    almost2years
    RAS Mutations in Adult Acute Myeloid Leukemia (AML). Frequency, Mutational Spectrum, and Identification of a Comutation Bias for KRASK117 (TET2/ASXL1) (ASH 2022)
    Complex and miscellaneous karyotypes showed KRAS mutations more often. KRASK117N mutations were consistently associated with TET2 and ASXL1 mutations and mutually exclusive with NPM1 and DNMT3A.
    Clinical
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    KRAS (KRAS proto-oncogene GTPase) • NRAS (Neuroblastoma RAS viral oncogene homolog) • NPM1 (Nucleophosmin 1) • DNMT3A (DNA methyltransferase 1) • ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • RAS (Rat Sarcoma Virus)
    |
    KRAS mutation • NRAS mutation • NPM1 mutation • DNMT3A mutation • RAS mutation • ASXL1 mutation • TET2 mutation • NRAS Q61K • NRAS Q61 • KRAS Q61 • HRAS K117N • HRAS Q61