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DRUG:

Genasense (oblimersen)

i
Other names: G3139, GC 3139
Associations
Company:
Genta
Drug class:
Bcl2 inhibitor
Related drugs:
Associations
10ms
Bcl-2 expression in cell lines breast cancer and death program. (PubMed, Cell Mol Biol (Noisy-le-grand))
Our team designed a new Antisense Oligonucleotide (ASO) based on Antisense oligo G3139. It also had a synergistic effect with the Tamoxifen. The cationic nano-complex (Niosome) was more efficient than the liposome in delivering designed oligo antisense Bcl-2 in the cancer cells.
Preclinical • Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2)
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BCL2 expression
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tamoxifen • Genasense (oblimersen)
1year
Phase classification
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BCL2 (B-cell CLL/lymphoma 2)
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Rituxan (rituximab) • doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone • Genasense (oblimersen)
over1year
Metal-Organic Frameworks Facilitate Nucleic Acids for Multimode Synergistic Therapy of Breast Cancer. (PubMed, Langmuir)
In this study, a chemotherapy drug-free nanotherapeutic system based on ZIF-90 encapsulated with Ce6-G3139 and Ce6-DNAzyme for gene and photodynamic therapies was constructed...In addition, the photosensitizer Ce6 carried by the nucleic acid will produce cytotoxic ROS to kill cancer cells after irradiation. The results of this study demonstrated that the designed nanoplatform, which synergistically combines gene and photodynamic therapies, has shown great potential for cancer treatment.
Journal
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BCL2 (B-cell CLL/lymphoma 2)
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Genasense (oblimersen)
almost2years
Bcl-2 pathway inhibition in solid tumors: a review of clinical trials. (PubMed, Clin Transl Oncol)
Throughout the years, many Bcl-2 family inhibitors have been developed, with Venetoclax being now successfully used in treating hematological malignancies...We managed to include clinical trials of various phases which analyze the pharmacokinetics and pharmacodynamics of the drugs, as well as the effectiveness and adverse effects. Active and recruiting clinical trials are also briefly presented and future prospects and challenges are discussed.
Review • Journal
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BCL2 (B-cell CLL/lymphoma 2)
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Venclexta (venetoclax) • navitoclax (ABT 263) • Genasense (oblimersen)
2years
Efficient Delivery of the Bcl-2 Antisense Oligonucleotide G3139 via Nucleus-Targeted aCD33-NKSN Nanoparticles. (PubMed, Int J Pharm)
The results illustrate that aCD33-NKSN/G3139 nanoparticles could improve the antitumor activity of encapsulated G3139 due to aCD33 targeting and the ability to perform nuclear localization, The results offer a promising clinical application potential for the treatment of acute myeloid leukemia. A R T I C L E I N F O.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • CD33 (CD33 Molecule)
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BCL2 expression
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Genasense (oblimersen)
over3years
Phase 3 randomized trial of chemotherapy with or without oblimersen in older AML patients: CALGB 10201 (Alliance). (PubMed, Blood Adv)
In a phase 1 study of AML patients treated with G3139, cytarabine, and daunorubicin induction with cytarabine consolidation, no antisense-related toxicity was reported, and BCL2 downregulation occurred in patients achieving complete remission. However, more effective means of inhibiting BCL2 are showing promising results in combination with chemotherapy in AML. This trial was registered at www.clinicaltrials.gov as #NCT00085124.
Clinical • P3 data • Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2)
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BCL2 overexpression
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cytarabine • daunorubicin • Genasense (oblimersen)