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DRUG:

FLX925

i
Other names: FLX925, AMG 925
Associations
Trials
Company:
RAPT Therap
Drug class:
CDK4 inhibitor, CDK6 inhibitor, FLT3 inhibitor
Related drugs:
Associations
Trials
over3years
High-throughput proteomic profiling reveals mechanisms of action of AMG925, a dual FLT3-CDK4/6 kinase inhibitor targeting AML and AML stem/progenitor cells. (PubMed, Ann Hematol)
Mass cytometry identified pathways that may confer resistance to AMG925 in phenotypically defined AML stem/progenitor cells and demonstrated that combined blockade of FLT3-CDK4/6 and AKT/mTOR signaling facilitated stem cell death. Our findings provide a rationale for the mechanism-based inhibition of FLT3-CDK4/6 and for combinatorial approaches to improve the efficacy of FLT3 inhibition in both FLT3 wild-type and FLT3-mutated AML.
Journal
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FLT3 (Fms-related tyrosine kinase 3) • CDK4 (Cyclin-dependent kinase 4)
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FLT3 mutation
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FLX925