everolimus

Sotorasib is a targeted therapy approved for the treatment of KRAS G12C-mutated non-small cell lung cancer and is known to induce cytochrome P450 3A4 and potentially modulate P-glycoprotein activity. Because calcineurin inhibitors and mechanistic target of rapamycin inhibitors have narrow therapeutic windows, even modest reductions in exposure may predispose to acute rejection. Transplant clinicians should closely monitor drug levels and coordinate care with oncology teams when initiating sotorasib to maintain adequate immunosuppression and protect graft function.

P2, N=333, Active, not recruiting, Pfizer | Trial primary completion date: Sep 2025 --> Mar 2026

P1, N=5, Recruiting, Xuanwu Hospital, Beijing | Initiation date: Nov 2025 --> Mar 2026

P2, N=106, Active, not recruiting, University of Wisconsin, Madison | Recruiting --> Active, not recruiting | Trial completion date: Dec 2026 --> Sep 2026 | Trial primary completion date: Dec 2025 --> Sep 2026

RNA-seq results showed that the combined therapeutic approach synergistically reduces cell viability and promotes apoptosis through the inhibition of the MYC signaling pathway. Everolimus-gemcitabine combination exhibits synergistic antitumor activity, offering a potential therapeutic strategy for R/R PTCL.

One year after these treatments started, everolimus (mTOR inhibitor) 10 mg p.o. was administered every day...Although recurrent diseases were temporally controlled by these multidisciplinary treatments for the last month, he died of multiple metastases six years later, after tumor recurrence was detected. This case underscores the potential for late recurrence even in rectal NET G1 with unfavorable histological features, highlighting the importance of long-term surveillance.

P2, N=60, Recruiting, Incyte Corporation | Not yet recruiting --> Recruiting

TYMS levels also impact the efficacy of everolimus, an FDA-approved mTOR inhibitor for patients with PanNET, underscoring the clinical significance of our findings. In summary, our study uncovers a new role of TYMS linking nucleotide metabolism to growth signaling pathways via the regulation of the AMPK-mTOR axis.

P3, N=240, Active, not recruiting, MedSIR | Recruiting --> Active, not recruiting

P1, N=20, Recruiting, National Institute of Allergy and Infectious Diseases (NIAID) | Initiation date: Sep 2025 --> Dec 2025 | Not yet recruiting --> Recruiting

This study presents a novel and effective strategy to induce the abscopal effect through a synergistic combination of targeted drug delivery, radiotherapy, and immunotherapy. The approach offers strong translational potential for improving radioimmunotherapy outcomes in renal and potentially other immunogenic cancers.

PIP mRNA expression and specific immune-stromal features are associated with resistance to EVE. These findings suggest the potential of PIP as a spatially resolved predictive biomarker for patient stratification in HR+/HER2- ABC.