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DRUG:

EndoTAG-1 (paclitaxel liposomal)

i
Other names: MBT 0206, MBT-0206, SB05, SB05PC
Associations
Company:
Medigene, Sinphar Pharma
Drug class:
Bcl2 inhibitor, Tubulin inhibitor
Related drugs:
Associations
over1year
Trial completion date • Trial primary completion date • Combination therapy • Metastases
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HER-2 (Human epidermal growth factor receptor 2)
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gemcitabine • EndoTAG-1 (paclitaxel liposomal)
almost2years
Paclitaxel-Loaded Cationic Fluid Lipid Nanodiscs and Liposomes with Brush-Conformation PEG Chains Penetrate Breast Tumors and Trigger Caspase-3 Activation. (PubMed, ACS Appl Mater Interfaces)
Carriers based on cationic liposomes (CLs) with fluid (i.e., chain-melted) membranes (e.g., EndoTAG-1) have shown promise in preclinical and late-stage clinical studies...At 5 and 10 mol % of a PEG-lipid (PEG5K-lipid, molecular weight of PEG 5000 g/mol), the mixture of PEGylated CLs and nanodiscs was able to incorporate up to 2.5 mol % PTX without crystallization for at least 20 h. Remarkably, compared to preparations containing 2 and 5 mol % PEG5K-lipid (with the PEG chains in the mushroom regime), the particles at 10 mol % (with PEG chains in the brush regime) showed significantly higher blood half-life, tumor penetration, and proapoptotic activity. Our study suggests that increasing the PEG coverage of CL-based drug nanoformulations can improve their pharmacokinetics and therapeutic efficacy.
Journal
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CASP3 (Caspase 3)
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EndoTAG-1 (paclitaxel liposomal)
almost2years
Trial suspension • Combination therapy • Metastases
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HER-2 (Human epidermal growth factor receptor 2)
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gemcitabine • EndoTAG-1 (paclitaxel liposomal)
over4years
Nanoparticle albumin-bound paclitaxel/liposomal-encapsulated doxorubicin in HER2-negative metastatic breast cancer patients. (PubMed, Future Oncol)
Aim: To investigate the toxicity of nab-paclitaxel (wNP)/nonpegylated liposome-encapsulated doxorubicin (wNPLD) combination in HER2-negative metastatic breast cancer (MBC) patients as first-line treatment. The objective response rate was 68% (response mean duration: 12.6 months). wNP/wNPLD combination constitutes an active regimen with mild toxicity.
Clinical • Journal
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HER-2 (Human epidermal growth factor receptor 2)
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HER-2 negative
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albumin-bound paclitaxel • EndoTAG-1 (paclitaxel liposomal) • doxorubicin liposomal