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    DRUG:

    DS-3078

    i
    Other names: DS-3078, DS-3078a
    Associations

    News

    Trials
    Company:
    Daiichi Sankyo
    Drug class:
    mTOR inhibitor
    Related drugs:
    Associations

    News

    Trials
    over3years
    Small molecule CDS-3078 induces G/M phase arrest and mitochondria-mediated apoptosis in HeLa cells. (PubMed, Exp Ther Med)
    Therefore, CDS-3078 administration induced apoptosis via p53-mediated cell cycle arrest, causing mitochondrial dysfunction and resulting in apoptotic cell death in cervical cancer cells. Collectively, the present results suggested that CDS-3078 may be a potential anticancer agent.
    Journal
    |
    BCL2 (B-cell CLL/lymphoma 2)
    |
    TP53 expression
    |
    DS-3078