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our Premium Content: News alerts, weekly reports and conference plannersDRUG:
DS-3078
i
Other names: DS-3078, DS-3078a
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Company:
Daiichi Sankyo
Drug class:
mTOR inhibitor
Related drugs:
almost4years
Small molecule CDS-3078 induces G/M phase arrest and mitochondria-mediated apoptosis in HeLa cells. (PubMed, Exp Ther Med)
Therefore, CDS-3078 administration induced apoptosis via p53-mediated cell cycle arrest, causing mitochondrial dysfunction and resulting in apoptotic cell death in cervical cancer cells. Collectively, the present results suggested that CDS-3078 may be a potential anticancer agent.
Journal
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BCL2 (B-cell CLL/lymphoma 2)
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TP53 expression
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DS-3078
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