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DRUG:

CTA101

i
Other names: CTA101, CTA101 UCAR-T cell injection, CTA 101, CTA-101
Associations
Trials
Company:
Nanjing Bioheng Biotech
Drug class:
CD19-targeted CAR-T immunotherapy, CD22-targeted CAR-T immunotherapy
Related drugs:
Associations
Trials
1year
CAR‑T Cell Therapy With CRISPR/CAS9 Engineering for Relapsed/Refractory B‑Cell Acute Lymphoblastic Leukemia, With Universal Dual Target CD19/CD22 (SOHO 2023)
The utilization of CRISPR/ Cas9 technology facilitated highly efficient and precise gene editing, resulting in the production of universal CAR-T cells. No genotoxicity or chromosomal translocation associated with gene editing was observed. Six patients received infusions of CTA101 at doses of 1 (3 patients) and 3 (3 patients) × 106 CAR+ T cells per kilogram of body weight.
CAR T-Cell Therapy
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CD22 (CD22 Molecule) • CD52 (CD52 Molecule)
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CTA101
over3years
CRISPR/Cas9-engineered universal CD19/CD22 dual-targeted CAR-T cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia. (PubMed, Clin Cancer Res)
CRISPR/Cas9-engineered universal CD19/CD22 CAR-T cells exhibited a manageable safety profile and prominent anti-leukemia activity. Universal dual-targeted CAR-T cell therapy may offer an alternative therapy for patients with r/r ALL.
Journal • CAR T-Cell Therapy
|
CD19 (CD19 Molecule) • CD22 (CD22 Molecule)
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CTA101
4years
[VIRTUAL] The Safety and Efficacy of a CRISPR/Cas9-Engineered Universal CAR-T Cell Product (CTA101) in Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia (ASH 2020)
Prior to CTA101 infusion, pts received pre-conditioning chemotherapy regimen consisting of cyclophosphamide, fludarabine and alemtuzumab...All pts experienced CRS (3 G1, 2 G2, 1 G3), and the G3 CRS recovered within 7 days with one dose of tocilizumab and glucocorticoids...Early data of cellular PK and efficacy illustrate that CRISPR gene editing does not curtail the expansion and anti-leukemia capacity of CAR-T. Updated data, including long term gene editing-related AEs, will be presented after further follow-up.
Clinical • CAR T-Cell Therapy • IO biomarker
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CD19 (CD19 Molecule)
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Campath (alemtuzumab) • fludarabine IV • Actemra IV (tocilizumab) • CTA101