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CLIC-1901
i
Other names: CLIC-1901, CLIC1901, autologous anti-CD19 chimeric antigen receptor T cells, CLIC 1901
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Company:
Ottawa Hospital Research Institute
Drug class:
CD19-targeted CAR-T immunotherapy
Related drugs:
1year
CLIC-01: CLIC-1901 for the Treatment of Patients With Relapsed/Refractory CD19 Positive Hematologic Malignancies (clinicaltrials.gov)
P1/2, N=60, Recruiting, Ottawa Hospital Research Institute | Trial completion date: Oct 2022 --> Oct 2037 | Trial primary completion date: Oct 2022 --> Oct 2024
Trial completion date • Trial primary completion date
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CD19 (CD19 Molecule)
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CD19 expression
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cyclophosphamide • CLIC-1901
almost2years
CLIC-01: Manufacture and distribution of non-cryopreserved CAR-T cells for patients with CD19 positive hematologic malignancies. (PubMed, Front Immunol)
We report initial results from a single-arm, open-label study to determine the safety and efficacy of in-house manufactured CD19 CAR-T cells (entitled CLIC-1901) in participants with relapsed/refractory CD19 positive hematologic malignancies...Participants underwent lymphodepletion with fludarabine and cyclophosphamide, followed by infusion of non-cryopreserved CAR-T cells...Our experience may provide helpful guidance for other jurisdictions seeking to create feasible and sustainable CAR-T cell programs in research-oriented yet resource-constrained settings. https://clinicaltrials.gov/ct2/show/NCT03765177, identifier NCT03765177.
Journal • CAR T-Cell Therapy
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CD19 (CD19 Molecule)
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CD19 positive
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cyclophosphamide • fludarabine IV • CLIC-1901
over2years
New P2 trial • CAR T-Cell Therapy
|
CD19 (CD19 Molecule)
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CD19 expression
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CLIC-1901
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