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CD19/CD22 CAR-T cell therapy
i
Other names: CD19/CD22 CAR-T cell therapy, CD19/CD22 chimeric antigen receptor T-cell therapy
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Company:
Shanghai Yake Biotech
Drug class:
CD19-targeted CAR-T immunotherapy, CD22-targeted CAR-T immunotherapy
Related drugs:
29d
Sequential CD19 and CD22 CAR-T Therapy for Newly Diagnosed Ph+ B-ALL (clinicaltrials.gov)
P2, N=28, Completed, Zhejiang University | Recruiting --> Completed | Phase classification: P1/2 --> P2 | N=50 --> 28 | Trial completion date: Mar 2025 --> Aug 2024 | Trial primary completion date: Mar 2024 --> Aug 2024
Trial completion • Phase classification • Enrollment change • Trial completion date • Trial primary completion date
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CD22 (CD22 Molecule)
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CD22 positive
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CD19/CD22 CAR-T cell therapy
1year
Sequential CD19 and CD22 chimeric antigen receptor T-cell therapy for childhood refractory or relapsed B-cell acute lymphocytic leukaemia: a single-arm, phase 2 study. (PubMed, Lancet Oncol)
This sequential strategy induced deep and sustained responses with an acceptable toxicity profile, and thus potentially provides long-term benefits for children with this condition.
P2 data • Clinical Trial,Phase II • Journal • CAR T-Cell Therapy
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CD22 (CD22 Molecule)
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CD19/CD22 CAR-T cell therapy • anti-CD22 CAR-T cell therapy
1year
Dasatinib and CAR-T Cell Therapy for Newly Diagnosed Ph-Positive Acute Lymphoblastic Leukemia in Adults (ASH 2023)
Dasatinib in combination with a two-week vincristine and glucocorticoids regimen were administered, followed by sequential infusions of CD19 and CD22 CAR-T cells. Conclusions Dasatinib in combination with CAR-T cell therapy has enabled chemotherapy-free treatment in newly diagnosed Ph-positive ALL. This treatment is characterized by high complete molecular response, high long-term survival, low toxicity and short treatment cycles.
Clinical • CAR T-Cell Therapy • IO biomarker
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ABL1 (ABL proto-oncogene 1) • CD22 (CD22 Molecule)
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BCR-ABL1 F317L • BCR-ABL1 Y253H • ABL1 F317L • ABL1 Y253H
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dasatinib • vincristine • CD19/CD22 CAR-T cell therapy • anti-CD22 CAR-T cell therapy
over3years
Sequential CD19 and CD22 CAR-T Therapy for Newly Diagnosed Ph+ B-ALL (clinicaltrials.gov)
P1/2, N=50, Recruiting, Zhejiang University
Clinical • New P1/2 trial
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CD19 (CD19 Molecule) • CD22 (CD22 Molecule)
|
CD22 positive
|
CD19/CD22 CAR-T cell therapy
almost4years
Sequential CD19 and CD22 CAR-T Therapy for Newly Diagnosed Ph- B-ALL (clinicaltrials.gov)
P1/2, N=50, Recruiting, Zhejiang University
Clinical • New P1/2 trial
|
CD19 (CD19 Molecule) • CD22 (CD22 Molecule)
|
CD22 positive
|
CD19/CD22 CAR-T cell therapy
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