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DRUG:

CD19.CAR-T

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Company:

Nagoya University Graduate School of Medicine

Drug class:

CD19-targeted CAR-T immunotherapy

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over2years

A Phase I Study of CD19 Chimeric Antigen Receptor-T Cells Generated By the PiggyBac Transposon Vector for Acute Lymphoblastic Leukemia (ASH 2021)

All patients receive 25mg/m 2 /d of fludarabine and 250mg/m 2 /d of cyclophosphamide for 3 days followed by a single infusion of CAR-T cells. CD19.CAR-T cell infusion produced by the piggyBac transposon gene engineering system was safe in cohort 1 of our study. As no patients had DLT in cohort 1, we are enrolling the patients in further cohorts.

over 2 years ago

P1 data • CAR T-Cell Therapy • IO biomarker

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CD19 (CD19 Molecule) • CD8 (cluster of differentiation 8) • CD28 (CD28 Molecule) • CCR7 (Chemokine (C-C motif) receptor 7)

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CD19 positive • CD19 expression

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cyclophosphamide • fludarabine IV • CD19.CAR-T