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    DRUG:

    BMS-986353

    i
    Other names: CD19-NEX-T, BMS-986353, CC-97540, NEX T CD19, CD19 NEX T
    Associations

    News

    Trials
    Company:
    BMS
    Drug class:
    CD19-targeted CAR-T immunotherapy
    Related drugs:
    Associations

    News

    Trials
    2ms
    A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis or Progressive Forms of Multiple Sclerosis (clinicaltrials.gov)
    P1, N=98, Recruiting, Juno Therapeutics, Inc., a Bristol-Myers Squibb Company | Trial completion date: Feb 2027 --> Jul 2027 | Trial primary completion date: Feb 2027 --> Jul 2027
    Trial completion date • Trial primary completion date
    |
    cyclophosphamide • fludarabine IV • BMS-986353
    2ms
    A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (clinicaltrials.gov)
    P1, N=129, Recruiting, Juno Therapeutics, Inc., a Bristol-Myers Squibb Company | N=43 --> 129
    Enrollment change • CAR T-Cell Therapy
    |
    cyclophosphamide • fludarabine IV • BMS-986353
    3ms
    A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis or Progressive Forms of Multiple Sclerosis (clinicaltrials.gov)
    P1, N=98, Recruiting, Juno Therapeutics, Inc., a Bristol-Myers Squibb Company | Not yet recruiting --> Recruiting
    Enrollment open
    |
    cyclophosphamide • fludarabine IV • BMS-986353
    3ms
    A Study of CC-97540 in Participants With Severe, Refractory Systemic Lupus Erythematosus (SLE) (clinicaltrials.gov)
    P1, N=43, Recruiting, Juno Therapeutics, Inc., a Bristol-Myers Squibb Company | Trial completion date: Feb 2028 --> Nov 2027 | Trial primary completion date: Feb 2028 --> Nov 2027
    Trial completion date • Trial primary completion date
    |
    cyclophosphamide • fludarabine IV • BMS-986353
    4ms
    A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis or Progressive Forms of Multiple Sclerosis (clinicaltrials.gov)
    P1, N=98, Not yet recruiting, Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
    New P1 trial
    |
    cyclophosphamide • fludarabine IV • BMS-986353
    over1year
    A Study of CC-97540, CD19-targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (clinicaltrials.gov)
    P1, N=80, Active, not recruiting, Juno Therapeutics, a Subsidiary of Celgene | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
    |
    BCL6 rearrangement • BCL2 rearrangement
    |
    cyclophosphamide • BMS-986353
    over1year
    A Study of CC-97540, CD19-targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (clinicaltrials.gov)
    P1, N=80, Recruiting, Juno Therapeutics, a Subsidiary of Celgene | Trial completion date: Jan 2025 --> Jun 2024 | Trial primary completion date: Jan 2025 --> Jun 2024
    Trial completion date • Trial primary completion date
    |
    BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
    |
    BCL6 rearrangement • BCL2 rearrangement
    |
    cyclophosphamide • BMS-986353
    almost4years
    A Study of CC-97540, CD19-targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (clinicaltrials.gov)
    P1, N=80, Recruiting, Juno Therapeutics, a Subsidiary of Celgene | Initiation date: Jan 2020 --> May 2020
    Clinical • Trial initiation date
    |
    BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
    |
    BCL6 rearrangement • BCL2 rearrangement
    |
    BMS-986353
    over4years
    A Study of CC-97540, CD19-targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (clinicaltrials.gov)
    P1, N=80, Recruiting, Juno Therapeutics, a Subsidiary of Celgene | Not yet recruiting --> Recruiting
    Clinical • Enrollment open
    |
    BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
    |
    BCL6 rearrangement • BCL2 rearrangement
    |
    BMS-986353