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DRUG:

CB-010

i
Other names: CB-010, CB010, CB 010
Company:
Caribou Biosci
Drug class:
CD19-targeted CAR-T immunotherapy
Related drugs:
11ms
Trial completion date • Trial primary completion date • CAR T-Cell Therapy
|
cyclophosphamide • fludarabine IV • CB-010
over1year
Allogeneic chimeric antigen receptor-T cells with CRISPR-disrupted programmed death-1 checkpoint exhibit enhanced functional fitness. (PubMed, Cytotherapy)
Genomic PD-1 checkpoint disruption in the context of allogeneic CAR-T cell therapy may provide a compelling option for treating B lymphoid malignancies.
Journal • CAR T-Cell Therapy
|
PD-L1 (Programmed death ligand 1) • PD-1 (Programmed cell death 1)
|
CB-010
2years
A First-in-Human Phase 1, Multicenter, Open-Label Study of CB-010, a Next-Generation CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy with a PD-1 Knockout, in Patients with Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER Study) (ASH 2022)
After serially receiving lymphodepletion therapy with cyclophosphamide (60mg/kg/day for 2 days) and fludarabine (25mg/m2/day for 5 days), pts receive a single dose infusion of CB-010 and are followed for safety and efficacy. Dose escalation of CB-010 is ongoing, and patients are being enrolled in cohort 2 to receive a single dose of 80 million CAR-T cells. The ANTLER Phase 1 trial is registered on clinicaltrials.gov (NCT04637763).
Clinical • P1 data • CAR T-Cell Therapy • PD(L)-1 Biomarker • IO biomarker
|
PD-1 (Programmed cell death 1)
|
cyclophosphamide • fludarabine IV • CB-010