^
    1m
    A Study to Investigate BGB-3245 (Brimarafenib) With Panitumumab in Participants With Advanced or Metastatic RAS Mutant Colorectal and Pancreatic Ductal Cancers (clinicaltrials.gov)
    P1, N=64, Recruiting, MapKure, LLC | Not yet recruiting --> Recruiting
    Enrollment open • Metastases
    |
    BRAF (B-raf proto-oncogene)
    |
    Vectibix (panitumumab) • brimarefenib (BGB-3245)
    4ms
    A Study to Investigate BGB-3245 (Brimarafenib) With Panitumumab in Participants With Advanced or Metastatic RAS Mutant Colorectal and Pancreatic Ductal Cancers (clinicaltrials.gov)
    P1, N=64, Not yet recruiting, MapKure, LLC
    New P1 trial • Metastases
    |
    BRAF (B-raf proto-oncogene)
    |
    Vectibix (panitumumab) • brimarefenib (BGB-3245)
    5ms
    BGB-3245-AU-001: Study of Safety, Pharmacokinetics, and Antitumor Activity of BGB-3245 in Participants With Advanced or Refractory Tumors (clinicaltrials.gov)
    P1, N=114, Recruiting, MapKure, LLC | Phase classification: P1a/1b --> P1
    Phase classification
    |
    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • NRAS (Neuroblastoma RAS viral oncogene homolog)
    |
    KRAS mutation • BRAF mutation • BRAF V600 • BRAF fusion
    |
    brimarefenib (BGB-3245)
    8ms
    BGB-3245-AU-001: Study of Safety, Pharmacokinetics, and Antitumor Activity of BGB-3245 in Participants With Advanced or Refractory Tumors (clinicaltrials.gov)
    P1a/1b, N=114, Recruiting, MapKure, LLC | Trial completion date: Aug 2024 --> Jun 2025 | Trial primary completion date: May 2024 --> Aug 2024
    Trial completion date • Trial primary completion date • Metastases
    |
    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • NRAS (Neuroblastoma RAS viral oncogene homolog)
    |
    KRAS mutation • BRAF mutation • BRAF V600 • BRAF fusion
    |
    brimarefenib (BGB-3245)
    9ms
    BGB-3245-AU-001: Study of Safety, Pharmacokinetics, and Antitumor Activity of BGB-3245 in Participants With Advanced or Refractory Tumors (clinicaltrials.gov)
    P1a/1b, N=114, Recruiting, MapKure, LLC | N=168 --> 114
    Enrollment change • Metastases
    |
    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • NRAS (Neuroblastoma RAS viral oncogene homolog)
    |
    KRAS mutation • BRAF mutation • BRAF V600 • BRAF fusion
    |
    brimarefenib (BGB-3245)
    over1year
    Mirdametinib + BGB-3245 in Advanced Solid Tumors (clinicaltrials.gov)
    P1/2, N=136, Recruiting, SpringWorks Therapeutics, Inc. | Not yet recruiting --> Recruiting
    Enrollment open • Combination therapy • Metastases
    |
    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • NRAS (Neuroblastoma RAS viral oncogene homolog)
    |
    KRAS mutation • BRAF mutation • NRAS mutation • BRAF fusion
    |
    mirdametinib (PD-0325901) • brimarefenib (BGB-3245)
    over1year
    BGB-3245-AU-001: Study of Safety, Pharmacokinetics, and Antitumor Activity of BGB-3245 in Participants With Advanced or Refractory Tumors (clinicaltrials.gov)
    P1a/1b, N=168, Recruiting, MapKure, LLC | Trial completion date: Jun 2023 --> Jun 2024 | Trial primary completion date: May 2023 --> May 2024
    Trial completion date • Trial primary completion date • Metastases
    |
    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • NRAS (Neuroblastoma RAS viral oncogene homolog)
    |
    KRAS mutation • BRAF mutation • NRAS mutation • BRAF V600 • BRAF fusion
    |
    brimarefenib (BGB-3245)
    over1year
    Mirdametinib + BGB-3245 in Advanced Solid Tumors (clinicaltrials.gov)
    P1/2, N=136, Not yet recruiting, SpringWorks Therapeutics, Inc.
    New P1/2 trial • Combination therapy • Metastases
    |
    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • NRAS (Neuroblastoma RAS viral oncogene homolog)
    |
    KRAS mutation • BRAF mutation • NRAS mutation • BRAF fusion
    |
    mirdametinib (PD-0325901) • brimarefenib (BGB-3245)
    over2years
    Study of Safety, Pharmacokinetics, and Antitumor Activity of BGB-3245 in Participants With Advanced or Refractory Tumors (clinicaltrials.gov)
    P1a/1b, N=168, Recruiting, MapKure, LLC | N=69 --> 168
    Enrollment change
    |
    BRAF (B-raf proto-oncogene) • NRAS (Neuroblastoma RAS viral oncogene homolog)
    |
    BRAF mutation • NRAS mutation • BRAF fusion
    |
    brimarefenib (BGB-3245)
    4years
    Study of Safety, Pharmacokinetics, and Antitumor Activity of BGB-3245 in Participants With Advanced or Refractory Tumors (clinicaltrials.gov)
    P1a/1b, N=69, Recruiting, MapKure, LLC | Not yet recruiting --> Recruiting
    Clinical • Enrollment open
    |
    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene)
    |
    KRAS mutation • NRAS mutation
    |
    brimarefenib (BGB-3245)
    over4years
    Study of Safety, Pharmacokinetics, and Antitumor Activity of BGB-3245 in Participants With Advanced or Refractory Tumors (clinicaltrials.gov)
    P1a/1b, N=69, Not yet recruiting, MapKure, LLC
    Clinical • New P1 trial
    |
    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene)
    |
    KRAS mutation • NRAS mutation
    |
    brimarefenib (BGB-3245)