Also, there was a concentration-dependent growth inhibition of in vitro cultured breast cancer cells treated with AgNPs and overexpression of p53 and Bax, and underexpression of Bcl-2. AgNPs synthesized by this method provide a potential source for antibacterial and anticancer applications.

almost 2 years ago

Journal • IO biomarker

TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein)

BAX expression • BCL2 underexpression

over3years

PANC-1 cancer stem-like cell death with silybin encapsulated in polymersomes and deregulation of stemness-related miRNAs and their potential targets. (PubMed, Iran J Basic Med Sci)

Under-expression of onco-miRs (miR-21, miR-155, and miR-221), over-expression of several apoptotic potential targets of oncomiRs (Bax, Casp-9, and P53), over-expression of tumor suppressive-miRs (let-7b, miR-34a, and miR-126), and under-expression of Bcl-2 was found in SPNs-treated cells. We suggest that silybin encapsulated in polymersomes (SPNs) may be useful as a complementary agent for destroying both pancreatic cancer cells and pancreatic CSCs along with chemotherapeutic agents.

over 3 years ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • CD44 (CD44 Molecule) • MIR155 (MicroRNA 155) • MIR21 (MicroRNA 21) • CD24 (CD24 Molecule) • MIR34A (MicroRNA 34a-5p) • CASP9 (Caspase 9) • MIR221 (MicroRNA 221) • MIR126 (MicroRNA 126)

BCL2 expression • TP53 overexpression • CD44 expression • miR-155 expression • BCL2 underexpression • CD133 expression • miR-21 overexpression