This updated preclinical dataset for ATA3219 demonstrates the flexibility of our EBV T-cell manufacturing process through improvements in the polyfunctional phenotype, potent expansion and targeting against B cell tumors with low alloreactivity. These findings support advancing ATA3219 to clinical evaluation.
Conclusions This preclinical dataset for CD19-1XX CAR+ EBV T cells demonstrates persistence, polyfunctional phenotype and efficient targeting of CD19-expressing tumor cells in vitro and in vivo, with limited allocytoxicity against antigen-negative, HLA-mismatched targets. These findings support advancing ATA3219 to clinical evaluation.
Conclusions This preclinical dataset for CD19-1XX CAR+ EBV T cells demonstrates persistence, polyfunctional phenotype and efficient targeting of CD19-expressing tumor cells in vitro and in vivo, with limited allocytoxicity against antigen-negative, HLA-mismatched targets. These findings support advancing ATA3219 to clinical evaluation.
Conclusions This preclinical dataset for CD19-1XX CAR+ EBV T cells demonstrates persistence, polyfunctional phenotype and efficient targeting of CD19-expressing tumor cells in vitro and in vivo, with limited allocytoxicity against antigen-negative, HLA-mismatched targets. These findings support advancing ATA3219 to clinical evaluation.
Conclusions This preclinical dataset for CD19-1XX CAR+ EBV T cells demonstrates persistence, polyfunctional phenotype and efficient targeting of CD19-expressing tumor cells in vitro and in vivo, with limited allocytoxicity against antigen-negative, HLA-mismatched targets. These findings support advancing ATA3219 to clinical evaluation.
Conclusions This preclinical dataset for CD19-1XX CAR+ EBV T cells demonstrates persistence, polyfunctional phenotype and efficient targeting of CD19-expressing tumor cells in vitro and in vivo, with limited allocytoxicity against antigen-negative, HLA-mismatched targets. These findings support advancing ATA3219 to clinical evaluation.
CONCLUSIONS This preclinical dataset for CD19-1XX CAR+ EBV T cells demonstrate, persistence, polyfunctional phenotype and efficient targeting of CD19-expressing tumor cells, both in vitro and in vivo, with limited allocytoxicity against antigen-negative, HLA-mismatched targets. These findings support advancing ATA3219 to clinical evaluation.