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    DRUG:

    astatine-211-parthanatine ([²¹¹At]PTT)

    i
    Other names: [²¹¹At]PTT
    Associations

    News

    Trials
    Company:
    Trevarx Biomedical
    Drug class:
    PARP inhibitor, Alpha radiation emitter
    Related drugs:
    Associations

    News

    Trials
    2years
    Pre-clinical investigation of astatine-211-parthanatine for high-risk neuroblastoma. (PubMed, Commun Biol)
    Reversible hematological and marrow toxicity was observed 72 hours post-treatment at the MTD, however full recovery was evident by 4 weeks post-therapy. These data support clinical development of [At]PTT for high-risk neuroblastoma.
    Preclinical • Journal • PARP Biomarker
    |
    PARP1 (Poly(ADP-Ribose) Polymerase 1)
    |
    astatine-211-parthanatine ([²¹¹At]PTT)