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    DRUG:

    AMG 208

    i
    Other names: AMG 208
    Associations

    News

    Trials
    Company:
    Amgen
    Drug class:
    c-MET inhibitor
    Related drugs:
    Associations

    News

    Trials
    4years
    The HOTAIR/miR-214/ST6GAL1 crosstalk modulates colorectal cancer procession through mediating sialylated c-Met via JAK2/STAT3 cascade. (PubMed, J Exp Clin Cancer Res)
    The HOTAIR/miR-214/ST6GAL1 axis commands the CRC malignancy by modifying c-Met with sialylation and activating JAK2/STAT3 pathway. Our study presents novel insights into CRC progression and provided prospective therapeutic target for CRC.
    Journal
    |
    MET (MET proto-oncogene, receptor tyrosine kinase) • JAK2 (Janus kinase 2)
    |
    AMG 208