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over1year
INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas (clinicaltrials.gov)
P1, N=13, Active, not recruiting, Pediatric Brain Tumor Consortium | Recruiting --> Active, not recruiting | N=28 --> 13
Enrollment closed • Enrollment change
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CD4 (CD4 Molecule)
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aderbasib (INCB7839)
almost2years
INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas (clinicaltrials.gov)
P1, N=28, Recruiting, Pediatric Brain Tumor Consortium | Trial completion date: Dec 2023 --> Jun 2024 | Trial primary completion date: Dec 2022 --> Dec 2023
Trial completion date • Trial primary completion date
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CD4 (CD4 Molecule)
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aderbasib (INCB7839)
over2years
Depleting receptor tyrosine kinases EGFR and HER2 overcomes resistance to EGFR inhibitors in colorectal cancer. (PubMed, J Exp Clin Cancer Res)
Our study shows that CRC resistance to EGFR inhibitors results primarily from the inability of the inhibitors to downregulate their target and that a PEPD-based combination treatment overcomes the resistance.
Journal
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HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • ADAM17 (ADAM Metallopeptidase Domain 17) • ADAM10 (ADAM Metallopeptidase Domain 10)
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KRAS mutation • EGFR mutation • BRAF mutation • PIK3CA mutation • HER-2 mutation • EGFR overexpression • PIK3CA expression • PIK3CA overexpression • KRAS expression
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Erbitux (cetuximab) • 5-fluorouracil • Vectibix (panitumumab) • aderbasib (INCB7839)
almost3years
INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas (clinicaltrials.gov)
P1, N=28, Recruiting, Pediatric Brain Tumor Consortium | Trial primary completion date: Mar 2022 --> Dec 2022
Trial primary completion date
|
CD4 (CD4 Molecule)
|
aderbasib (INCB7839)
3years
INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas (clinicaltrials.gov)
P1, N=28, Recruiting, Pediatric Brain Tumor Consortium | Active, not recruiting --> Recruiting
Clinical • Enrollment open
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CD4 (CD4 Molecule)
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aderbasib (INCB7839)