^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    ABCB1 G1236T + ABCB1 G2677T

    i
    Other names: ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1, ATP-binding cassette, sub-family B (MDR/TAP), member 1
    Entrez ID:
    5243
    Related biomarkers:
    Expression
    Mutation
    4years
    Intracellular vincristine levels in lymphoblasts affect treatment outcome in childhood B-lymphoblastic leukaemia: Ma-Spore ALL 2010 Study. (PubMed, Br J Clin Pharmacol)
    We showed that in childhood B-ALL, the intracellular VCR levels in lymphoblasts affected treatment outcomes. The intracellular VCR level was independent of leukaemia subtype but dependent on host ABCB1 G2677T genotype.
    Clinical • Journal
    |
    ABCB1 (ATP Binding Cassette Subfamily B Member 1)
    |
    ABCB1 G1236T + ABCB1 G2677T • ABCB1 G2677T
    |
    vincristine
    over4years
    Association between ABCB1 G2677T/A Polymorphism and Breast Cancer Risk: A Meta-Analysis. (PubMed, Crit Rev Eukaryot Gene Expr)
    Similarly, no significant association was observed in the stratification analyses by ethnicity and control source. In conclusion, this meta-analysis suggests that ABCB1 G2677T/A polymorphism is not associated with genetic susceptibility to breast cancer.
    Retrospective data • Journal
    |
    ABCB1 (ATP Binding Cassette Subfamily B Member 1)
    |
    ABCB1 G1236T + ABCB1 G2677T • ABCB1 G2677T