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DRUG:
AB011
i
Other names:
AB011 , AB-011, AB 011
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Associations
(2)
News
Trials
Company:
CARsgen
Drug class:
CLDN18.2 inhibitor
Related drugs:
‹
zolbetuximab-clzb (11)
ZL-1211 (4)
TJ-CD4B (4)
AZD5863 (3)
ASP2138 (2)
TST001 (2)
MIL93 (1)
Q-1802 (1)
ASKB589 (0)
BNT141 (0)
DR30303 (0)
FL-301 (0)
IBI-389 (0)
IBI360 (0)
LB4330 (0)
LM-102 (0)
PM1032 (0)
PM3023 (0)
PT886 (0)
QLS31905 (0)
SG1906 (0)
TAC101-Claudin18.2 (0)
AMG 910 (0)
zolbetuximab-clzb (11)
ZL-1211 (4)
TJ-CD4B (4)
AZD5863 (3)
ASP2138 (2)
TST001 (2)
MIL93 (1)
Q-1802 (1)
ASKB589 (0)
BNT141 (0)
DR30303 (0)
FL-301 (0)
IBI-389 (0)
IBI360 (0)
LB4330 (0)
LM-102 (0)
PM1032 (0)
PM3023 (0)
PT886 (0)
QLS31905 (0)
SG1906 (0)
TAC101-Claudin18.2 (0)
AMG 910 (0)
›
Associations
(2)
News
Trials
Filter by
Latest
6ms
Clinical Trial to Evaluate AB011 Injection in Patients With CLDN18.2-positive Advanced Solid Tumors (clinicaltrials.gov)
P1, N=62, Completed, CARsgen Therapeutics Co., Ltd. | Active, not recruiting --> Completed | Trial completion date: Jun 2024 --> Sep 2023
6 months ago
Trial completion • Trial completion date
|
CLDN18 (Claudin 18)
|
capecitabine • oxaliplatin • AB011
almost2years
Clinical Trial to Evaluate AB011 Injection in Patients With CLDN18.2-positive Advanced Solid Tumors (clinicaltrials.gov)
P1, N=62, Active, not recruiting, CARsgen Therapeutics Co., Ltd. | Recruiting --> Active, not recruiting | N=197 --> 62 | Trial primary completion date: Dec 2022 --> Jul 2023
almost 2 years ago
Enrollment closed • Enrollment change • Trial primary completion date • Metastases
|
CLDN18 (Claudin 18)
|
CLDN18.2 positive
|
capecitabine • oxaliplatin • AB011
almost2years
A multicenter, phase 1 study of AB011, a recombinant humanized anti-CLDN18.2 monoclonal antibody, as monotherapy and combined with capecitabine and oxaliplatin (CAPOX) in patients with advanced solid tumors. (ASCO-GI 2023)
These results indicate that AB011, either in monotherapy or combined with chemotherapy, had a manageable safety profile and encouraging efficacy in CLDND18.2 positive advanced GC/GEJA and PC. Clinical trial information: NCT04400383.
almost 2 years ago
Clinical • P1 data • Metastases
|
CLDN18 (Claudin 18) • CLDN8 (Claudin 8)
|
CLDN18.2 expression • CLDN18.2 positive
|
capecitabine • oxaliplatin • AB011
almost3years
Clinical Trial to Evaluate AB011 Injection in Patients With CLDN18.2-positive Advanced Solid Tumors (clinicaltrials.gov)
P1, N=197, Recruiting, CARsgen Therapeutics Co., Ltd. | N=103 --> 197 | Trial primary completion date: May 2022 --> Dec 2022
almost 3 years ago
Enrollment change • Trial primary completion date
|
CLDN18 (Claudin 18)
|
CLDN18.2 positive
|
AB011
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