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DRUG:

Vyloy (zolbetuximab-clzb)

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Company:

Astellas

Drug class:

CLDN18.2 inhibitor

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CLDN18.2 positive + HER-2 negative	Gastroesophageal Junction Adenocarcinoma	CLDN18.2 positive + HER-2 negative	Gastroesophageal Junction Adenocarcinoma	zolbetuximab-clzb Sensitive: A1 - Approval zolbetuximab-clzb Sensitive : A1	zolbetuximab-clzb Sensitive: A1 - Approval zolbetuximab-clzb Sensitive : A1
CLDN18.2 positive + HER-2 negative	Gastric Cancer	CLDN18.2 positive + HER-2 negative	Gastric Cancer	zolbetuximab-clzb Sensitive: A1 - Approval zolbetuximab-clzb Sensitive : A1	zolbetuximab-clzb Sensitive: A1 - Approval zolbetuximab-clzb Sensitive : A1
CLDN18.2 expression + HER-2 negative	Gastroesophageal Junction Adenocarcinoma	CLDN18.2 expression + HER-2 negative	Gastroesophageal Junction Adenocarcinoma	zolbetuximab-clzb Sensitive: B - Late Trials zolbetuximab-clzb Sensitive : B	zolbetuximab-clzb Sensitive: B - Late Trials zolbetuximab-clzb Sensitive : B
CLDN18.2 expression + HER-2 negative	Gastric Cancer	CLDN18.2 expression + HER-2 negative	Gastric Cancer	zolbetuximab-clzb Sensitive: B - Late Trials zolbetuximab-clzb Sensitive : B	zolbetuximab-clzb Sensitive: B - Late Trials zolbetuximab-clzb Sensitive : B
CLDN18.2 expression	Esophageal Adenocarcinoma	CLDN18.2 expression	Esophageal Adenocarcinoma	zolbetuximab-clzb Sensitive: C2 – Inclusion Criteria zolbetuximab-clzb Sensitive : C2	zolbetuximab-clzb Sensitive: C2 – Inclusion Criteria zolbetuximab-clzb Sensitive : C2
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CLDN18.2 expression	Gastric Adenocarcinoma	CLDN18.2 expression	Gastric Adenocarcinoma	zolbetuximab-clzb Sensitive: C2 – Inclusion Criteria zolbetuximab-clzb Sensitive : C2	zolbetuximab-clzb Sensitive: C2 – Inclusion Criteria zolbetuximab-clzb Sensitive : C2
CLDN18.2 positive	Gastroesophageal Junction Adenocarcinoma	CLDN18.2 positive	Gastroesophageal Junction Adenocarcinoma	zolbetuximab-clzb Sensitive: C2 – Inclusion Criteria zolbetuximab-clzb Sensitive : C2	zolbetuximab-clzb Sensitive: C2 – Inclusion Criteria zolbetuximab-clzb Sensitive : C2
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CLDN18.2 overexpression	Gastric Cancer	CLDN18.2 overexpression	Gastric Cancer	zolbetuximab-clzb Sensitive: C3 – Early Trials zolbetuximab-clzb Sensitive : C3	zolbetuximab-clzb Sensitive: C3 – Early Trials zolbetuximab-clzb Sensitive : C3
CLDN18.2 positive	Gastric Adenocarcinoma	CLDN18.2 positive	Gastric Adenocarcinoma	zolbetuximab-clzb Sensitive: C3 – Early Trials zolbetuximab-clzb Sensitive : C3	zolbetuximab-clzb Sensitive: C3 – Early Trials zolbetuximab-clzb Sensitive : C3