COMPANY:

ANGLE

"ANGLE plc...is pleased to announce the presentation of an independent study, reporting on a novel, Parsortix®-based human epidermal growth factor receptor 2 (HER2) workflow at the prominent San Antonio Breast Cancer Symposium being held from 10 to 13 December 2024...The findings, published by Weill Cornell Medicine, corroborate ANGLE's own findings from its HER2 assay development programme, and provide a semi-automated solution which may help to accelerate adoption of CTC-based HER2 tests. HER2 status is known to change in a significant proportion of breast cancer patients over time, so a minimally invasive, real-time assay is needed for dynamic HER2 assessment to enable targeted treatment selection and detection of emerging treatment resistance or progression."

"ANGLE plc...announce its participation at the European Association for Cancer Research (EACR) Liquid Biopsies Conference being held in Lyon, France from 12 to 14 November 2024."

"ANGLE plc...is pleased to announce the publication of new data at the American Association for Cancer Research (AACR) Special Conference in Cancer Research in San Diego, US from 13 to 16 November 2024...ANGLE is presenting a poster entitled the 'Development of a scoring system to classify HER2 protein expression in Circulating Tumor Cells through immunofluorescence following isolation using Parsortix® instruments' and reports on progress of the Company's co-development programme with BioView."

"ANGLE plc...is pleased to announce the publication of new data at the American Association for Cancer Research (AACR) Special Conference in Cancer Research, Liquid Biopsy: From Discovery to Clinical Implementation, in San Diego, US from 13 to 16 November 2024."

"ANGLE plc...is pleased to announce its participation at the European Association for Cancer Research (EACR) Liquid Biopsies Conference being held in Lyon, France from 12 to 14 November 2024...ANGLE presented two posters at the EACR Liquid Biopsies Conference...This poster presentation reports on the utility of combining ANGLE's Parsortix® system for CTC capture with the Portrait®+ CTC staining kit for CTC detection and phenotypic characterisation...This proof-of-concept study demonstrates that using amplitude-based multiplexing with QIAGEN's Qiacuity dPCR system can increase the number of genes that can be assessed simultaneously in a Parsortix-enriched CTC sample."

"ANGLE plc...is pleased to announce the publication of research investigating the dual analysis of CTCs and circulating tumour DNA (ctDNA) in non-small cell lung cancer (NSCLC), undertaken by the National and Kapodistrian University of Athens. Researchers used the Parsortix® system to isolate and harvest CTCs from 30 patients with EGFR-mutated NSCLC that were undergoing treatment with osimertinib (TAGRISSO: AstraZeneca). Osimertinib is an EGFR inhibitor with annual revenues of c. US$6.7 billion, growing at c. 16% per annum. Both CTCs and ctDNA were analysed using a range of molecular techniques which enabled the identification of mutations, methylation, gene expression and amplification."

"ANGLE plc...announce the publication of research investigating a panel of known prostate cancer gene transcripts in CTCs, undertaken by the Comprehensive Cancer Center at the Medical University of Vienna...Researchers used the Parsortix®system to isolate and harvest CTCs from 38 localised and metastatic prostate cancer patients. CTCs were then analysed using a range of molecular techniques which enabled multiple biomarkers to be simultaneously analysed."

"ANGLE plc...is pleased to announce the publication of the 100th peer-reviewed journal article using the Parsortix® system for the isolation, harvest and analysis of CTCs...The journal article is published by researchers from a leading international referral centre for the treatment and study of cancer, the Fondazione IRCCS - Istituto Nazionale dei Tumori Di Milano (Italy)."

"ANGLE plc...is delighted to announce that it has signed an agreement with the cutting-edge genomics and molecular diagnostics company, NuProbe USA, Inc...to use its proprietary pan-cancer next generation sequencing (NGS) panel...Combining the Parsortix system with comprehensive DNA molecular analysis opens up a broad range of pharma services opportunities."

"ANGLE plc...is pleased to announce that it has signed an agreement with Recursion Pharmaceuticals, Inc...New pharma agreement for Parsortix CTC analysis...The agreement is being initiated with a fully funded pilot study."

"ANGLE plc...is pleased to announce the publication of one of the Company's clinical studies that was submitted to the FDA for De Novo regulatory clearance of the Parsortix® PC1 system...This study, undertaken at ANGLE's UK laboratory, the University of Rochester, US, and the MD Anderson Cancer Center, US, reports that the Parsortix system successfully captured and harvested CTCs from metastatic breast cancer (MBC) patient blood samples for downstream analysis using immunofluorescence (IF) and cytological evaluation."

"ANGLE plc...is pleased to announce the results of an independent study in melanoma patients comparing gene mutations in tumour tissue, circulating tumour DNA (ctDNA) and CTCs...The study, from Dr Laura Keller's team at the Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Germany, used the Parsortix® system to isolate CTCs from melanoma patient blood samples. The CTCs were analysed alongside tumour tissue and ctDNA samples using PCR (for gene amplification) followed by mass spectrometry."

"ANGLE plc...is pleased to announce its participation at the 2024 Annual Congress of the European Association for Cancer Research (EACR 2024) being held in Rotterdam, Netherlands from 10 to 13 June 2024."

"ANGLE plc...is delighted to announce the publication of a study using the Parsortix® system to identify markers present in CTCs harvested from metastatic mutant-p53 platinum-resistant ovarian cancer (PROC) patients. The study was conducted as an offshoot of the European multi-centre GANNET53 Phase II clinical trial (NCT02012192) funded by the EU 7th Framework Programme (Grant agreement ID: 602602). The study investigated the efficacy of ganetespib in combination with paclitaxel vs. paclitaxel alone. Patients were enrolled across 12 clinical centres in Germany, Belgium, France, and Austria."

"ANGLE plc...is delighted to announce that it has signed a supplier agreement to develop a Parsortix-based Androgen Receptor1 (AR) detection assay for use in prostate cancer studies. The supplier agreement reported here is with AstraZeneca...This follows an earlier agreement to develop a methodology for CTC micronuclei detection using the Company's DNA Damage Response (DDR) assay, announced on 24 April 2024."

"ANGLE plc...has signed a supplier agreement with the global biopharmaceutical company, AstraZeneca PLC, to develop and validate a methodology leveraging ANGLE's existing DNA damage response ('DDR') assay for the detection of micronuclei in CTCs as a measure of DDR."

"ANGLE plc...is pleased to announce that the European Patent Office has granted a European Patent for its innovative CellKeep™ slide. A formal communication has also been received from the United States Patent and Trademark Office indicating that grant of the equivalent US patent application is imminent."

"ANGLE plc...announce its participation at the American Association for Cancer Research (AACR) Annual Meeting, San Diego, US between 5 to 10 April 2024...ANGLE is presenting a poster entitled the 'Development and analytical validation of a novel assay for HER2 assessment on circulating tumor cells harvested using the Parsortix® system and incorporating BioView imaging technologies'."

"ANGLE plc...is pleased to announce its participation at the 14th European Breast Cancer Conference (EBCC) being held in Milan, Italy on 20 to 22 March 2024...ANGLE presenting two posters highlighting the utility of the Company's new Portrait+ CTC Staining Kit and Portrait HER2 assay"

"ANGLE plc...is pleased to announce the publication of a peer-reviewed paper in a special issue of the journal - 'Current Issues in Molecular Biology' Special Issue: Advanced Solutions for Cancer Therapy...This peer-reviewed article brings together supporting evidence for the additional and complementary information that can be obtained from CTCs using the Parsortix® system, demonstrating the value of a dual analyte approach for both CTCs and ctDNA."

"ANGLE plc...is delighted to announce breakthrough results from DNA molecular analysis of cancer patient blood samples that provide a unique insight into the progression of each patient's cancer and how this may be treated...Combined DNA Next Generation Sequencing of CTCs and ctDNA from the same blood sample highlights potential for the Parsortix system to identify key variants (DNA mutations) missed by other approaches to help guide treatment decisions..."

"ANGLE plc...is delighted to announce that it has signed a contract with the global pharmaceutical company, Eisai Inc. ('Eisai')...Under the agreement, in a pilot study worth US $250,000 to ANGLE, ANGLE will provide CTC analysis with its Portrait HER2 assay to assess breast cancer patients' HER2 (human epidermal growth factor receptor 2) status in a Phase II study of the HER2 targeting antibody-drug conjugate (ADC) BB-1701. Success in the pilot study offers the potential for multiple large scale follow-up studies."

"ANGLE plc...is delighted to announce the publication of breakthrough work by researchers at the University of New Mexico, US, into the role of CTC gene expression in the progression of melanoma brain metastasis. The researchers used the Parsortix system to harvest CTCs for analysis and concluded that '… gene expression in CTCs could be pivotal to prescribing more targeted treatment based on the needs of the patient.'"

"ANGLE plc...is delighted to announce the launch of its Portrait®+ CTC staining kit at the San Antonio Breast Cancer Symposium (SABCS)...This launch follows extensive development, optimisation and validation of the kit to provide advanced immunofluorescent (IF) staining of CTCs harvested from a patient blood sample by the Parsortix technology."

"ANGLE plc...is delighted to announce the launch of its Portrait® PD-L1 test for the evaluation of PD-L1 protein expression on CTCs following extensive development and optimisation. The test is provided as a service from ANGLE's Onc-ADaPT® GCP-compliant laboratories and is conducted by an expert team with over 10 years' experience in CTC analysis."

"ANGLE plc...is pleased to announce the publication of a study using the Parsortix system that sheds new light on the phenotypic characteristics of CTCs in Head and Neck Squamous Cell Carcinoma (HNSCC)...The study, conducted by researchers at the University of Birmingham, UK, demonstrates the feasibility of using mass cytometry, a powerful technique widely used for single cell analysis, for the comprehensive characterisation of CTCs captured by the Parsortix system in HNSCC patients."

"ANGLE plc...announces the publication of a study of disseminated tumour cells (DTCs) in bone marrow from breast cancer patients published in the International Journal of Molecular Sciences...Researchers at the University of Tübingen, Germany, used the Parsortix® system for the isolation and harvest of DTCs from bone marrow samples in 360 breast cancer patients (clinical stages I-IV) and compared results to the standard density centrifugation method for DTC detection."

"ANGLE plc...is pleased to announce its participation at the 6th Advances in Circulating Tumor Cells (ACTC) conference held in Greece from 20-23 September 2023...This included the presentation of nine posters showcasing the Parsortix® system in six cancer types across eight independent study centres."

"ANGLE plc...is pleased to announce the launch of its Portrait™ Flex CTC assay...The assay is provided as a service from ANGLE's Onc-ADaPT™ GCP-compliant laboratories and conducted by an expert team with over 10 years' experience in CTC analysis...The Portrait Flex assay has an analytical sensitivity...of >93%, and an analytical specificity...of >95% for both epithelial and mesenchymal markers."

"ANGLE plc...is delighted to announce that its first bespoke assay development customer, Artios Pharma (Artios), has signed a new contract to utilise two DNA Damage Response assays developed by ANGLE in a Phase 1 clinical trial expected to commence shortly...Artios selected ANGLE to develop immunofluorescence (IF) assays using its Parsortix system to detect two specific biomarkers expressed on circulating tumour cells (CTCs). The expression of the two biomarkers indicate the amount of DNA damage caused in a cell."

"ANGLE plc...is delighted to announce it has signed an agreement with BioView Ltd...to develop a liquid biopsy circulating tumor cell (CTC) HER2 assay for breast cancer utilising ANGLE's FDA cleared Parsortix® PC1 Clinical System to harvest CTCs and BioView's automated microscopy systems and software to detect and assess the HER2 expression and/or gene amplification in CTCs."

"ANGLE plc...is pleased to announce the presentation of a poster at the American Association for Cancer Research (AACR) annual meeting, in Orlando, Florida, United States, between 14-19 April 2023. The poster presents successful development work undertaken by ANGLE since FDA clearance to develop protocols to combine immunofluorescent (IF) staining for epithelial, mesenchymal and epithelial-to-mesenchymal (EMT) phenotype characterisation of circulating tumour cells (CTCs) with HER2 fluorescence in-situ hybridization (FISH) staining for gene amplification assessment on samples from blood processed using the Parsortix® system."

"ANGLE plc...is delighted to announce that it has signed a contract with a new customer, Crescendo Biologics Limited...Crescendo will use ANGLE's recently launched Portrait Flex assay in its ongoing Phase 1 clinical trial (NCT04839991) investigating the safety and efficacy of CB307, Crescendo's first-in-class prostate-specific membrane antigen (PSMA) x CD137 half-life extended bispecific, for the treatment of patients with PSMA positive solid tumours."

"ANGLE plc...is pleased to announce the presentation of two posters at the San Antonio Breast Cancer Symposium (SABCS), in San Antonio, Texas, United States, between 06-10 December 2022. The studies demonstrated the successful isolation and subsequent analysis of circulating tumour cells (CTCs) from Metastatic Breast Cancer (MBC) patient blood samples using the Parsortix® PC1 Clinical System."

"ANGLE plc...announce the publication of results from a multi-centre clinical study undertaken with The University of Texas MD Anderson Cancer Center, TX, Wilmot Cancer Institute, University of Rochester, NY, Robert H Lurie Comprehensive Cancer Center, Northwestern University, IL, and Norris Comprehensive Cancer Center, University of Southern California, CA, US. The Parsortix® system was used to enrich circulating tumour cells (CTCs) from 207 patients with metastatic breast cancer (MBC) with each patient providing two blood tubes allowing for testing of multiple downstream analytical techniques."

"ANGLE plc...is pleased to announce it presented results from a proof of concept study at the International Society of Liquid Biopsy meeting in Miami, Florida on 20-22 October 2022...The results show that removal of plasma from blood samples for circulating tumour DNA (ctDNA) analysis does not impact on the number or quality of circulating tumour cells (CTCs) which can be successfully isolated from the same sample using the Parsortix® system."

"ANGLE plc...is pleased to announce it has signed a distribution agreement with Promedeus s.r.o to enable and support the roll out of the FDA cleared and CE marked Parsortix® PC1 system across the Czech Republic for its intended use in metastatic breast cancer."

"ANGLE plc...is delighted to announce positive headline results from its ovarian cancer clinical verification study, demonstrating that a Parsortix® blood test can be used to determine if a woman is at risk of a malignant pelvic mass."

"ANGLE plc...is pleased to announce that the University of Birmingham has published the results of a study undertaken in head and neck squamous cell carcinoma (HNSCC) which characterised the epithelial-mesenchymal transition (EMT) status of circulating tumour cells (CTCs)...The study used the Parsortix® system to harvest CTCs from peripheral blood samples from 20 treatment-naïve HNSCC patients at baseline prior to surgery."

"ANGLE plc...is delighted to announce that its United States clinical laboratory team presented a new poster at the 100th American Society for Clinical Pathology (ASCP) meeting in Chicago, Illinois, USA between 7-9 September 2022. The poster, which describes the novel use of Papanicolaou (Pap) staining procedures with cells harvested from blood samples using the Parsortix® system, was selected as a finalist for a prestigious Blue Ribbon award for laboratory practice by ASCP judges."

"ANGLE plc...is delighted to announce the publication of results from a clinical study undertaken in partnership with the Wilmot Cancer Institute, University of Rochester, NY, US. The Parsortix® system was utilised for cancer detection in 183 women with a pelvic mass who had a range of benign and malignant conditions. The results have been published in the respected, high impact, journal Obstetrics & Gynecology ('The Green Journal')."

"ANGLE plc...is pleased to announce details of a new separate study...The study used the Parsortix® system to harvest CTCs from whole blood samples from 46 early-stage non-small cell lung cancer (NSCLC) patients, to analyse the expression of Metabolism-Related Genes (MRGs). Use of the biomarker-independent Parsortix system also allowed the researchers to investigate the association of MRG expression with epithelial and epithelial to mesenchymal transition (EMT) markers."