^
Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

YES1 as a Therapeutic Target for HER2-Positive Breast Cancer after Trastuzumab and Trastuzumab-Emtansine (T-DM1) Resistance Development

Published date:
11/26/2021
Excerpt:
YES1 was amplified in BT-474-R and further amplified in BT-474-R/TDR (Figure 3A)....In both assays, the combination of T-DM1 with dasatinib was found to be effective in BT-474-R and BT-474-R/TDR....In BT-474-R/TDR, there was no apoptosis with dasatinib alone, but apoptosis was induced by the combination therapy.
DOI:
10.3390/ijms222312809