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DRUG:
Xpovio (selinexor)
i
Other names:
KPT-330, KPT-330-003, SINE KPT-330, KPT330, ONO7705, KPT 330, ATG-010, ONO-7705, ONO 7705, ATG010, ATG 010
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Associations
(47)
News
Trials
Company:
Antengene, FORUS Therap, Jiangsu Hansoh Pharma, Karyopharm, Menarini, NeoPharm
Drug class:
XPO1 inhibitor
Related drugs:
‹
KPT-8602 (5)
CBS9106 (1)
KPT-8602 (5)
CBS9106 (1)
›
Associations
(47)
News
Trials
VERI cancer hierarchy
Reset Filters
No biomarker
Multiple Myeloma
No biomarker
Multiple Myeloma
selinexor
Sensitive: A1 - Approval
selinexor
Sensitive
:
A1
selinexor
Sensitive: A1 - Approval
selinexor
Sensitive
:
A1
No biomarker
Diffuse Large B Cell Lymphoma
No biomarker
Diffuse Large B Cell Lymphoma
selinexor
Sensitive: A1 - Approval
selinexor
Sensitive
:
A1
selinexor
Sensitive: A1 - Approval
selinexor
Sensitive
:
A1
No biomarker
Multiple Myeloma
No biomarker
Multiple Myeloma
selinexor + pomalidomide
Sensitive: A2 - Guideline
selinexor + pomalidomide
Sensitive
:
A2
selinexor + pomalidomide
Sensitive: A2 - Guideline
selinexor + pomalidomide
Sensitive
:
A2
No biomarker
Multiple Myeloma
No biomarker
Multiple Myeloma
selinexor + daratumumab
Sensitive: A2 - Guideline
selinexor + daratumumab
Sensitive
:
A2
selinexor + daratumumab
Sensitive: A2 - Guideline
selinexor + daratumumab
Sensitive
:
A2
No biomarker
Multiple Myeloma
No biomarker
Multiple Myeloma
selinexor + carfilzomib
Sensitive: A2 - Guideline
selinexor + carfilzomib
Sensitive
:
A2
selinexor + carfilzomib
Sensitive: A2 - Guideline
selinexor + carfilzomib
Sensitive
:
A2
Chr del(17p)
Multiple Myeloma
Chr del(17p)
Multiple Myeloma
bortezomib + selinexor
Sensitive: B - Late Trials
bortezomib + selinexor
Sensitive
:
B
bortezomib + selinexor
Sensitive: B - Late Trials
bortezomib + selinexor
Sensitive
:
B
No biomarker
Multiple Myeloma
No biomarker
Multiple Myeloma
selinexor
Sensitive: B - Late Trials
selinexor
Sensitive
:
B
selinexor
Sensitive: B - Late Trials
selinexor
Sensitive
:
B
No biomarker
Liposarcoma
No biomarker
Liposarcoma
selinexor
Sensitive: B - Late Trials
selinexor
Sensitive
:
B
selinexor
Sensitive: B - Late Trials
selinexor
Sensitive
:
B
GRM1 overexpression
Liposarcoma
GRM1 overexpression
Liposarcoma
selinexor
Sensitive: B - Late Trials
selinexor
Sensitive
:
B
selinexor
Sensitive: B - Late Trials
selinexor
Sensitive
:
B
CALB1 underexpression
Liposarcoma
CALB1 underexpression
Liposarcoma
selinexor
Sensitive: B - Late Trials
selinexor
Sensitive
:
B
selinexor
Sensitive: B - Late Trials
selinexor
Sensitive
:
B
CALB1 deletion
Liposarcoma
CALB1 deletion
Liposarcoma
selinexor
Sensitive: B - Late Trials
selinexor
Sensitive
:
B
selinexor
Sensitive: B - Late Trials
selinexor
Sensitive
:
B
TP53 wild-type
Endometrial Cancer
TP53 wild-type
Endometrial Cancer
selinexor
Sensitive: B - Late Trials
selinexor
Sensitive
:
B
selinexor
Sensitive: B - Late Trials
selinexor
Sensitive
:
B
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
selinexor
Sensitive: C2 – Inclusion Criteria
selinexor
Sensitive
:
C2
selinexor
Sensitive: C2 – Inclusion Criteria
selinexor
Sensitive
:
C2
NRAS mutation
Multiple Myeloma
NRAS mutation
Multiple Myeloma
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
RAS mutation
Multiple Myeloma
RAS mutation
Multiple Myeloma
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
KRAS mutation
Multiple Myeloma
KRAS mutation
Multiple Myeloma
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
IDH2 R172K
Acute Myelogenous Leukemia
IDH2 R172K
Acute Myelogenous Leukemia
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
pembrolizumab + selinexor
Sensitive: C3 – Early Trials
pembrolizumab + selinexor
Sensitive
:
C3
pembrolizumab + selinexor
Sensitive: C3 – Early Trials
pembrolizumab + selinexor
Sensitive
:
C3
RAS mutation
Colorectal Cancer
RAS mutation
Colorectal Cancer
pembrolizumab + selinexor
Sensitive: C3 – Early Trials
pembrolizumab + selinexor
Sensitive
:
C3
pembrolizumab + selinexor
Sensitive: C3 – Early Trials
pembrolizumab + selinexor
Sensitive
:
C3
NRAS mutation
Colorectal Cancer
NRAS mutation
Colorectal Cancer
pembrolizumab + selinexor
Sensitive: C3 – Early Trials
pembrolizumab + selinexor
Sensitive
:
C3
pembrolizumab + selinexor
Sensitive: C3 – Early Trials
pembrolizumab + selinexor
Sensitive
:
C3
Chr del(17p)
Multiple Myeloma
Chr del(17p)
Multiple Myeloma
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
DOCK8 mutation
Glioblastoma
DOCK8 mutation
Glioblastoma
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
EP400 mutation
Glioblastoma
EP400 mutation
Glioblastoma
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
PDX1 mutation
Glioblastoma
PDX1 mutation
Glioblastoma
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
venetoclax + selinexor
Sensitive: C3 – Early Trials
venetoclax + selinexor
Sensitive
:
C3
venetoclax + selinexor
Sensitive: C3 – Early Trials
venetoclax + selinexor
Sensitive
:
C3
PTGS2 expression
Rectal Cancer
PTGS2 expression
Rectal Cancer
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
CD177 expression
Rectal Cancer
CD177 expression
Rectal Cancer
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
TP53 mutation
Myelodysplastic Syndrome
TP53 mutation
Myelodysplastic Syndrome
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
selinexor
Sensitive: C3 – Early Trials
selinexor
Sensitive
:
C3
SF3B1 K666N
Chronic Myeloid Leukemia
SF3B1 K666N
Chronic Myeloid Leukemia
venetoclax + selinexor
Sensitive: D – Preclinical
venetoclax + selinexor
Sensitive
:
D
venetoclax + selinexor
Sensitive: D – Preclinical
venetoclax + selinexor
Sensitive
:
D
SF3B1 K666N
B Acute Lymphoblastic Leukemia
SF3B1 K666N
B Acute Lymphoblastic Leukemia
venetoclax + selinexor
Sensitive: D – Preclinical
venetoclax + selinexor
Sensitive
:
D
venetoclax + selinexor
Sensitive: D – Preclinical
venetoclax + selinexor
Sensitive
:
D
SF3B1 K666N
B Acute Lymphoblastic Leukemia
SF3B1 K666N
B Acute Lymphoblastic Leukemia
selinexor
Sensitive: D – Preclinical
selinexor
Sensitive
:
D
selinexor
Sensitive: D – Preclinical
selinexor
Sensitive
:
D
KRAS G12C
Non Small Cell Lung Cancer
KRAS G12C
Non Small Cell Lung Cancer
selinexor + MRTX1257
Sensitive: D – Preclinical
selinexor + MRTX1257
Sensitive
:
D
selinexor + MRTX1257
Sensitive: D – Preclinical
selinexor + MRTX1257
Sensitive
:
D
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