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BIOMARKER:
TMB-H + PD-L1 expression
i
Other names:
PD-L1, CD274, HPD-L1, PD-L1, B7H1, PDL1, Programmed death ligand 1, B7-H1, B7-H, PDCD1L1, PDCD1LG1, PDCD1 Ligand 1, B7 homolog 1, CD274 Antigen, Programmed cell death 1 ligand 1, CD274 molecule
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Entrez ID:
29126
Related biomarkers:
Expression
Mutation
CNA
Others
‹
NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)
PD-L1 rs1411262 (1)
PD-L1 rs2297136 (1)
PD-L1 rs4143815 (1)
PD-L1 rs822339 (1)
PD-L1 T290M (0)
PD-L1 mutation (0)
NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)
PD-L1 rs1411262 (1)
PD-L1 rs2297136 (1)
PD-L1 rs4143815 (1)
PD-L1 rs822339 (1)
PD-L1 T290M (0)
PD-L1 mutation (0)
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Associations
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Trials
VERI cancer hierarchy
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TMB-H + PD-L1 expression
Triple Negative Breast Cancer
TMB-H + PD-L1 expression
Triple Negative Breast Cancer
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
TMB-H + PD-L1 expression
Urothelial Cancer
TMB-H + PD-L1 expression
Urothelial Cancer
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
TMB-H + PD-L1 expression
Small Cell Lung Cancer
TMB-H + PD-L1 expression
Small Cell Lung Cancer
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
TMB-H + PD-L1 expression
Urothelial Cancer
TMB-H + PD-L1 expression
Urothelial Cancer
durvalumab + tremelimumab
Sensitive: C3 – Early Trials
durvalumab + tremelimumab
Sensitive
:
C3
durvalumab + tremelimumab
Sensitive: C3 – Early Trials
durvalumab + tremelimumab
Sensitive
:
C3
TMB-H + PD-L1 expression
Urothelial Cancer
TMB-H + PD-L1 expression
Urothelial Cancer
nivolumab
Sensitive: C3 – Early Trials
nivolumab
Sensitive
:
C3
nivolumab
Sensitive: C3 – Early Trials
nivolumab
Sensitive
:
C3
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
TMB-H + PD-L1 expression
Colorectal Cancer
TMB-H + PD-L1 expression
Colorectal Cancer
nivolumab + pimitespib
Sensitive: C3 – Early Trials
nivolumab + pimitespib
Sensitive
:
C3
nivolumab + pimitespib
Sensitive: C3 – Early Trials
nivolumab + pimitespib
Sensitive
:
C3
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
anlotinib + sintilimab
Sensitive: C3 – Early Trials
anlotinib + sintilimab
Sensitive
:
C3
anlotinib + sintilimab
Sensitive: C3 – Early Trials
anlotinib + sintilimab
Sensitive
:
C3
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
sintilimab
Sensitive: C3 – Early Trials
sintilimab
Sensitive
:
C3
sintilimab
Sensitive: C3 – Early Trials
sintilimab
Sensitive
:
C3
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
nivolumab + ipilimumab
Sensitive: C3 – Early Trials
nivolumab + ipilimumab
Sensitive
:
C3
nivolumab + ipilimumab
Sensitive: C3 – Early Trials
nivolumab + ipilimumab
Sensitive
:
C3
TMB-H + PD-L1 expression
Penile Cancer
TMB-H + PD-L1 expression
Penile Cancer
toripalimab-tpzi
Sensitive: C4 – Case Studies
toripalimab-tpzi
Sensitive
:
C4
toripalimab-tpzi
Sensitive: C4 – Case Studies
toripalimab-tpzi
Sensitive
:
C4
TMB-H + PD-L1 expression
Squamous Cell Skin Cancer
TMB-H + PD-L1 expression
Squamous Cell Skin Cancer
pembrolizumab + panitumumab
Sensitive: C4 – Case Studies
pembrolizumab + panitumumab
Sensitive
:
C4
pembrolizumab + panitumumab
Sensitive: C4 – Case Studies
pembrolizumab + panitumumab
Sensitive
:
C4
TMB-H + PD-L1 expression
Urothelial Cancer
TMB-H + PD-L1 expression
Urothelial Cancer
pembrolizumab
Sensitive: C4 – Case Studies
pembrolizumab
Sensitive
:
C4
pembrolizumab
Sensitive: C4 – Case Studies
pembrolizumab
Sensitive
:
C4
TMB-H + PD-L1 expression
Soft Tissue Sarcoma
TMB-H + PD-L1 expression
Soft Tissue Sarcoma
anlotinib + toripalimab-tpzi
Sensitive: C4 – Case Studies
anlotinib + toripalimab-tpzi
Sensitive
:
C4
anlotinib + toripalimab-tpzi
Sensitive: C4 – Case Studies
anlotinib + toripalimab-tpzi
Sensitive
:
C4
TMB-H + PD-L1 expression
Lung Cancer
TMB-H + PD-L1 expression
Lung Cancer
pembrolizumab
Sensitive: C4 – Case Studies
pembrolizumab
Sensitive
:
C4
pembrolizumab
Sensitive: C4 – Case Studies
pembrolizumab
Sensitive
:
C4
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