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Association details:
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Title:

Potential immune escape mechanisms underlying the distinct clinical outcome of immune checkpoint blockades in small cell lung cancer

Published date:
06/28/2019
Excerpt:
Only atezolizumab in combination with chemotherapy improved overall survival over chemotherapy alone… selecting tumor mutation burden in combination with PD-L1 expression as biomarkers could be promising strategies to improve the clinical efficacy of immunotherapy for SCLC... SCLC, with a high TMB similar to that of NSCLC, is theoretically likely to respond to immunotherapy.
DOI:
10.1186/s13045-019-0753-2