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BIOMARKER:
TMB-H + PD-L1 expression
i
Other names:
PD-L1, CD274, HPD-L1, PD-L1, B7H1, PDL1, Programmed death ligand 1, B7-H1, B7-H, PDCD1L1, PDCD1LG1, PDCD1 Ligand 1, B7 homolog 1, CD274 Antigen, Programmed cell death 1 ligand 1, CD274 molecule
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Entrez ID:
29126
Related biomarkers:
Expression
Mutation
CNA
Others
‹
PD-L1 expression (356)
PD-L1 overexpression (181)
PD-L1 underexpression (46)
PD-L1 negative (28)
HER-2 negative + PD-L1 expression (12)
HER-2 positive + PD-L1 expression (3)
HR negative + PD-L1 expression (2)
MSLN overexpression + PD-L1 overexpression (2)
PD-L1 expression + CD68 positive (2)
PD-L1 expression + HER-2 overexpression (2)
PD-L1 expression + PVR expression (2)
PD-L1 overexpression + CD8 overexpression (2)
TTF1 expression + PD-L1 expression (2)
miR-625-5p underexpression + PD-L1 overexpression (2)
AXL overexpression + PD-L1 expression (1)
CGAS overexpression + PD-L1 overexpression (1)
CMTM4 expression + PD-L1 expression (1)
CMTM6 expression + PD-L1 expression (1)
CMTM6 overexpression + PD-L1 overexpression (1)
CXCL12 expression + PD-L1 underexpression (1)
HLA-A underexpression + PD-L1 expression (1)
HR positive + PD-L1 expression (1)
IGFBP2 overexpression + PD-L1 overexpression (1)
MHC-II overexpression + PD-L1 negative (1)
MHC-II overexpression + PD-L1 underexpression (1)
NKX2-1 expression + PD-L1 expression (1)
NR1H4 overexpression + PD‑L1 underexpression (1)
NT5E overexpression + PD-L1 expression (1)
PD-1 underexpression + PD-L1 overexpression (1)
PD-L1 expression + CD14 positive (1)
PD-L1 expression + CD47 expression (1)
PD-L1 expression + CD8 negative + GZMB negative (1)
PD-L1 expression + CD8 positive (1)
PD-L1 expression + CTLA4 expression (1)
PD-L1 expression + MTOR overexpression (1)
PD-L1 expression + REV3L overexpression (1)
PD-L1 overexpression + APOBEC3B overexpression (1)
PD-L1 overexpression + CCL5 overexpression (1)
PD-L1 overexpression + CD163 underexpression (1)
PD-L1 overexpression + ER positive (1)
PD-L1 overexpression + GZMA overexpression (1)
PD-L1 overexpression + LAG3 expression + CTAG1B expression (1)
PD-L1 overexpression + PD-L2 underexpression (1)
PD-L1 overexpression + SOX2 overexpression (1)
RBM17 expression + PD-L1 expression (1)
RET positive + PD-L1 overexpression (1)
SNX20 overexpression + PD-L1 overexpression (1)
STK11 underexpression + PD-L1 overexpression (1)
TFRC overexpression + PD-L1 underexpression (1)
TNFSF4 overexpression + PD-L1 overexpression (1)
TTF1 expression + PD-L1 overexpression (1)
HER-2 negative + HR negative + PD-L1 expression (0)
PD-L1 expression + HER-2 expression (0)
PD-L1 expression + LAG3 expression (0)
PD-L1 expression + TTF1 expression (0)
TMB + PD-L1 expression (0)
PD-L1 expression (356)
PD-L1 overexpression (181)
PD-L1 underexpression (46)
PD-L1 negative (28)
HER-2 negative + PD-L1 expression (12)
HER-2 positive + PD-L1 expression (3)
HR negative + PD-L1 expression (2)
MSLN overexpression + PD-L1 overexpression (2)
PD-L1 expression + CD68 positive (2)
PD-L1 expression + HER-2 overexpression (2)
PD-L1 expression + PVR expression (2)
PD-L1 overexpression + CD8 overexpression (2)
TTF1 expression + PD-L1 expression (2)
miR-625-5p underexpression + PD-L1 overexpression (2)
AXL overexpression + PD-L1 expression (1)
CGAS overexpression + PD-L1 overexpression (1)
CMTM4 expression + PD-L1 expression (1)
CMTM6 expression + PD-L1 expression (1)
CMTM6 overexpression + PD-L1 overexpression (1)
CXCL12 expression + PD-L1 underexpression (1)
HLA-A underexpression + PD-L1 expression (1)
HR positive + PD-L1 expression (1)
IGFBP2 overexpression + PD-L1 overexpression (1)
MHC-II overexpression + PD-L1 negative (1)
MHC-II overexpression + PD-L1 underexpression (1)
NKX2-1 expression + PD-L1 expression (1)
NR1H4 overexpression + PD‑L1 underexpression (1)
NT5E overexpression + PD-L1 expression (1)
PD-1 underexpression + PD-L1 overexpression (1)
PD-L1 expression + CD14 positive (1)
PD-L1 expression + CD47 expression (1)
PD-L1 expression + CD8 negative + GZMB negative (1)
PD-L1 expression + CD8 positive (1)
PD-L1 expression + CTLA4 expression (1)
PD-L1 expression + MTOR overexpression (1)
PD-L1 expression + REV3L overexpression (1)
PD-L1 overexpression + APOBEC3B overexpression (1)
PD-L1 overexpression + CCL5 overexpression (1)
PD-L1 overexpression + CD163 underexpression (1)
PD-L1 overexpression + ER positive (1)
PD-L1 overexpression + GZMA overexpression (1)
PD-L1 overexpression + LAG3 expression + CTAG1B expression (1)
PD-L1 overexpression + PD-L2 underexpression (1)
PD-L1 overexpression + SOX2 overexpression (1)
RBM17 expression + PD-L1 expression (1)
RET positive + PD-L1 overexpression (1)
SNX20 overexpression + PD-L1 overexpression (1)
STK11 underexpression + PD-L1 overexpression (1)
TFRC overexpression + PD-L1 underexpression (1)
TNFSF4 overexpression + PD-L1 overexpression (1)
TTF1 expression + PD-L1 overexpression (1)
HER-2 negative + HR negative + PD-L1 expression (0)
PD-L1 expression + HER-2 expression (0)
PD-L1 expression + LAG3 expression (0)
PD-L1 expression + TTF1 expression (0)
TMB + PD-L1 expression (0)
›
Associations
News
Trials
VERI cancer hierarchy
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TMB-H + PD-L1 expression
Triple Negative Breast Cancer
TMB-H + PD-L1 expression
Triple Negative Breast Cancer
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
TMB-H + PD-L1 expression
Urothelial Cancer
TMB-H + PD-L1 expression
Urothelial Cancer
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
atezolizumab
Sensitive: B - Late Trials
atezolizumab
Sensitive
:
B
TMB-H + PD-L1 expression
Small Cell Lung Cancer
TMB-H + PD-L1 expression
Small Cell Lung Cancer
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
TMB-H + PD-L1 expression
Urothelial Cancer
TMB-H + PD-L1 expression
Urothelial Cancer
durvalumab + tremelimumab
Sensitive: C3 – Early Trials
durvalumab + tremelimumab
Sensitive
:
C3
durvalumab + tremelimumab
Sensitive: C3 – Early Trials
durvalumab + tremelimumab
Sensitive
:
C3
TMB-H + PD-L1 expression
Urothelial Cancer
TMB-H + PD-L1 expression
Urothelial Cancer
nivolumab
Sensitive: C3 – Early Trials
nivolumab
Sensitive
:
C3
nivolumab
Sensitive: C3 – Early Trials
nivolumab
Sensitive
:
C3
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
TMB-H + PD-L1 expression
Colorectal Cancer
TMB-H + PD-L1 expression
Colorectal Cancer
nivolumab + pimitespib
Sensitive: C3 – Early Trials
nivolumab + pimitespib
Sensitive
:
C3
nivolumab + pimitespib
Sensitive: C3 – Early Trials
nivolumab + pimitespib
Sensitive
:
C3
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
anlotinib + sintilimab
Sensitive: C3 – Early Trials
anlotinib + sintilimab
Sensitive
:
C3
anlotinib + sintilimab
Sensitive: C3 – Early Trials
anlotinib + sintilimab
Sensitive
:
C3
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
sintilimab
Sensitive: C3 – Early Trials
sintilimab
Sensitive
:
C3
sintilimab
Sensitive: C3 – Early Trials
sintilimab
Sensitive
:
C3
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
TMB-H + PD-L1 expression
Non Small Cell Lung Cancer
nivolumab + ipilimumab
Sensitive: C3 – Early Trials
nivolumab + ipilimumab
Sensitive
:
C3
nivolumab + ipilimumab
Sensitive: C3 – Early Trials
nivolumab + ipilimumab
Sensitive
:
C3
TMB-H + PD-L1 expression
Penile Cancer
TMB-H + PD-L1 expression
Penile Cancer
toripalimab-tpzi
Sensitive: C4 – Case Studies
toripalimab-tpzi
Sensitive
:
C4
toripalimab-tpzi
Sensitive: C4 – Case Studies
toripalimab-tpzi
Sensitive
:
C4
TMB-H + PD-L1 expression
Squamous Cell Skin Cancer
TMB-H + PD-L1 expression
Squamous Cell Skin Cancer
pembrolizumab + panitumumab
Sensitive: C4 – Case Studies
pembrolizumab + panitumumab
Sensitive
:
C4
pembrolizumab + panitumumab
Sensitive: C4 – Case Studies
pembrolizumab + panitumumab
Sensitive
:
C4
TMB-H + PD-L1 expression
Urothelial Cancer
TMB-H + PD-L1 expression
Urothelial Cancer
pembrolizumab
Sensitive: C4 – Case Studies
pembrolizumab
Sensitive
:
C4
pembrolizumab
Sensitive: C4 – Case Studies
pembrolizumab
Sensitive
:
C4
TMB-H + PD-L1 expression
Soft Tissue Sarcoma
TMB-H + PD-L1 expression
Soft Tissue Sarcoma
anlotinib + toripalimab-tpzi
Sensitive: C4 – Case Studies
anlotinib + toripalimab-tpzi
Sensitive
:
C4
anlotinib + toripalimab-tpzi
Sensitive: C4 – Case Studies
anlotinib + toripalimab-tpzi
Sensitive
:
C4
TMB-H + PD-L1 expression
Lung Cancer
TMB-H + PD-L1 expression
Lung Cancer
pembrolizumab
Sensitive: C4 – Case Studies
pembrolizumab
Sensitive
:
C4
pembrolizumab
Sensitive: C4 – Case Studies
pembrolizumab
Sensitive
:
C4
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