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GENE:

SOX2

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TheraSure™-CNI MONITOR Assay

TheraSure™-CNI MONITOR Assay

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PD-L1 overexpression + SOX2 overexpression	Melanoma	PD-L1 overexpression + SOX2 overexpression	Melanoma	PD1 inhibitor Resistant: C3 – Early Trials PD1 inhibitor Resistant : C3	PD1 inhibitor Resistant: C3 – Early Trials PD1 inhibitor Resistant : C3
SOX2 overexpression	Estrogen Receptor Positive Breast Cancer	SOX2 overexpression	Estrogen Receptor Positive Breast Cancer	tamoxifen Resistant: C3 – Early Trials tamoxifen Resistant : C3	tamoxifen Resistant: C3 – Early Trials tamoxifen Resistant : C3
SOX2 overexpression	Triple Negative Breast Cancer	SOX2 overexpression	Triple Negative Breast Cancer	EGFR-targeted antibody-drug conjugate Resistant: C3 – Early Trials EGFR-targeted antibody-drug conjugate Resistant : C3	EGFR-targeted antibody-drug conjugate Resistant: C3 – Early Trials EGFR-targeted antibody-drug conjugate Resistant : C3
SOX2 expression	Prostate Cancer	SOX2 expression	Prostate Cancer	Immunotherapy Resistant: C3 – Early Trials Immunotherapy Resistant : C3	Immunotherapy Resistant: C3 – Early Trials Immunotherapy Resistant : C3
BRAF V600E + SOX2 amplification	Glioblastoma	BRAF V600E + SOX2 amplification	Glioblastoma	trametinib + dabrafenib Sensitive: C4 – Case Studies trametinib + dabrafenib Sensitive : C4	trametinib + dabrafenib Sensitive: C4 – Case Studies trametinib + dabrafenib Sensitive : C4