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Association details:
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
Title:

Recurrence biomarkers of triple negative breast cancer treated with neoadjuvant chemotherapy and anti-EGFR antibodies

Published date:
09/17/2021
Excerpt:
Six patients experienced a rapid fatal recurrence (RR) and other 6 had later non-fatal recurrences (LR)...RR cases showed high expression of SOX2 and CXCR4. Our results indicate that high expression of cell cycle genes, combined with cold immunological phenotype, may predict strong TNBC resistance to NAT and rapid progression after it.
Secondary therapy:
Chemotherapy
DOI:
https://doi.org/10.1038/s41523-021-00334-5