^
    Back
    Association details:
    Biomarker:SOX2 expression
    Cancer:Prostate Cancer
    Drug Class:Immunotherapy
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: C3 – Early Trials
    Source:
    Eur Urol Oncol
    Title:

    Immune Biomarkers in Metastatic Castration-resistant Prostate Cancer

    Published date:
    04/28/2022
    Excerpt:
    To study the prevalence of immune biomarkers of potential clinical utility to immunotherapy in mCRPC and to determine their association with overall survival (OS)….PD-L1 protein expression (aHR: 1.90 [1.05; 3.45]), high TcellinfGEP score (aHR: 1.86 [1.04; 3.31]), and SOX2 expression (aHR: 2.09 [1.20; 3.64]) were associated with worse OS.
    DOI:
    https://doi.org/10.1016/j.euo.2022.04.004