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DRUG:

Revuforj (revumenib)

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News alerts, weekly reports and conference planners

Company:

Syndax Pharma

Drug class:

Menin-MLL inhibitor

Related drugs:

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NPM1 mutation	Acute Myelogenous Leukemia	NPM1 mutation	Acute Myelogenous Leukemia	revumenib Sensitive: B - Late Trials revumenib Sensitive : B	revumenib Sensitive: B - Late Trials revumenib Sensitive : B
MLL rearrangement	Acute Myelogenous Leukemia	MLL rearrangement	Acute Myelogenous Leukemia	revumenib Sensitive: B - Late Trials revumenib Sensitive : B	revumenib Sensitive: B - Late Trials revumenib Sensitive : B
KMT2A rearrangement	Acute Myelogenous Leukemia	KMT2A rearrangement	Acute Myelogenous Leukemia	revumenib Sensitive: B - Late Trials revumenib Sensitive : B	revumenib Sensitive: B - Late Trials revumenib Sensitive : B
MLL rearrangement	Leukemia	MLL rearrangement	Leukemia	revumenib Sensitive: C2 – Inclusion Criteria revumenib Sensitive : C2	revumenib Sensitive: C2 – Inclusion Criteria revumenib Sensitive : C2
NPM1 mutation	Leukemia	NPM1 mutation	Leukemia	revumenib Sensitive: C2 – Inclusion Criteria revumenib Sensitive : C2	revumenib Sensitive: C2 – Inclusion Criteria revumenib Sensitive : C2
KMT2A rearrangement + NPM1 mutation	Acute Myelogenous Leukemia	KMT2A rearrangement + NPM1 mutation	Acute Myelogenous Leukemia	revumenib Sensitive: C3 – Early Trials revumenib Sensitive : C3	revumenib Sensitive: C3 – Early Trials revumenib Sensitive : C3
NUP98 rearrangement	Acute Myelogenous Leukemia	NUP98 rearrangement	Acute Myelogenous Leukemia	venetoclax + revumenib Sensitive: C3 – Early Trials venetoclax + revumenib Sensitive : C3	venetoclax + revumenib Sensitive: C3 – Early Trials venetoclax + revumenib Sensitive : C3
NPM1 mutation	Acute Myelogenous Leukemia	NPM1 mutation	Acute Myelogenous Leukemia	venetoclax + revumenib Sensitive: C3 – Early Trials venetoclax + revumenib Sensitive : C3	venetoclax + revumenib Sensitive: C3 – Early Trials venetoclax + revumenib Sensitive : C3
KMT2A rearrangement	Acute Myelogenous Leukemia	KMT2A rearrangement	Acute Myelogenous Leukemia	venetoclax + revumenib Sensitive: C3 – Early Trials venetoclax + revumenib Sensitive : C3	venetoclax + revumenib Sensitive: C3 – Early Trials venetoclax + revumenib Sensitive : C3
NUP98-NSD1 fusion + FLT3-ITD mutation	Acute Myelogenous Leukemia	NUP98-NSD1 fusion + FLT3-ITD mutation	Acute Myelogenous Leukemia	revumenib Sensitive: D – Preclinical revumenib Sensitive : D	revumenib Sensitive: D – Preclinical revumenib Sensitive : D
NPM1 expression	Acute Myelogenous Leukemia	NPM1 expression	Acute Myelogenous Leukemia	revumenib Sensitive: D – Preclinical revumenib Sensitive : D	revumenib Sensitive: D – Preclinical revumenib Sensitive : D
KMT2A expression	Acute Myelogenous Leukemia	KMT2A expression	Acute Myelogenous Leukemia	revumenib Sensitive: D – Preclinical revumenib Sensitive : D	revumenib Sensitive: D – Preclinical revumenib Sensitive : D
KMT2A rearrangement + RAS mutation	B Acute Lymphoblastic Leukemia	KMT2A rearrangement + RAS mutation	B Acute Lymphoblastic Leukemia	selumetinib + revumenib Sensitive: D – Preclinical selumetinib + revumenib Sensitive : D	selumetinib + revumenib Sensitive: D – Preclinical selumetinib + revumenib Sensitive : D
KMT2A rearrangement + RAS mutation	Acute Myelogenous Leukemia	KMT2A rearrangement + RAS mutation	Acute Myelogenous Leukemia	selumetinib + revumenib Sensitive: D – Preclinical selumetinib + revumenib Sensitive : D	selumetinib + revumenib Sensitive: D – Preclinical selumetinib + revumenib Sensitive : D
FLT3-ITD mutation + NPM1 mutation	Acute Myelogenous Leukemia	FLT3-ITD mutation + NPM1 mutation	Acute Myelogenous Leukemia	revumenib + FHD-286 Sensitive: D – Preclinical revumenib + FHD-286 Sensitive : D	revumenib + FHD-286 Sensitive: D – Preclinical revumenib + FHD-286 Sensitive : D
MLL-AF4 fusion	Acute Myelogenous Leukemia	MLL-AF4 fusion	Acute Myelogenous Leukemia	revumenib + ORY-1001 Sensitive: D – Preclinical revumenib + ORY-1001 Sensitive : D	revumenib + ORY-1001 Sensitive: D – Preclinical revumenib + ORY-1001 Sensitive : D
MLL rearrangement	Acute Myelogenous Leukemia	MLL rearrangement	Acute Myelogenous Leukemia	revumenib + ORY-1001 Sensitive: D – Preclinical revumenib + ORY-1001 Sensitive : D	revumenib + ORY-1001 Sensitive: D – Preclinical revumenib + ORY-1001 Sensitive : D
KMT2A rearrangement	Acute Myelogenous Leukemia	KMT2A rearrangement	Acute Myelogenous Leukemia	revumenib + ORY-1001 Sensitive: D – Preclinical revumenib + ORY-1001 Sensitive : D	revumenib + ORY-1001 Sensitive: D – Preclinical revumenib + ORY-1001 Sensitive : D