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    Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors (CRESTONE) (NCT04383210)
    Phase 2
    Elevation Oncology
    Active, not recruiting
    Last update posted :
    08/08/2023
    Initiation :
    09/29/2020
    Primary completion :
    01/01/2025
    Completion :
    03/01/2025
    NRG1
    |
    NRG1 fusion
    |
    seribantumab (MM-121)
    A Study of MM-121 in Combination With Paclitaxel in Patients With Advanced Gynecologic and Breast Cancers (NCT01209195)
    Phase 1
    Merrimack Pharmaceuticals
    Completed
    Last update posted :
    09/08/2016
    Initiation :
    10/01/2010
    Primary completion :
    05/01/2014
    Completion :
    07/01/2014
    HER-2
    |
    HER-2 overexpression
    |
    paclitaxel • seribantumab (MM-121)
    Phase I Safety Study of the Drug MM-121 in Patients With Advanced Solid Tumors Resisting Ordinary Treatment (NCT00734305)
    Phase 1
    Merrimack Pharmaceuticals
    Completed
    Last update posted :
    09/01/2016
    Initiation :
    07/01/2008
    Primary completion :
    05/01/2010
    Completion :
    09/01/2013
    HER-2 • PGR
    |
    seribantumab (MM-121)
    Trial of Exemestane +/- MM-121 in Postmenopausal Women With Locally Advanced or Metastatic Estrogen Receptor Positive and/or Progesterone Receptor Positive Her2 Negative Breast Cancer (NCT01151046)
    Phase 2
    Merrimack Pharmaceuticals
    Completed
    Last update posted :
    05/12/2016
    Initiation :
    06/01/2010
    Primary completion :
    06/01/2014
    Completion :
    09/01/2014
    HER-2
    |
    HER-2 negative
    |
    exemestane • seribantumab (MM-121)
    A Trial of Preoperative MM-121 With Paclitaxel in HER2-negative Breast Cancer (NCT01421472)
    Phase 2
    Merrimack Pharmaceuticals
    Completed
    Last update posted :
    05/03/2016
    Initiation :
    08/01/2011
    Primary completion :
    12/01/2013
    Completion :
    06/01/2014
    HER-2 • ER
    |
    ER positive • HER-2 negative
    |
    paclitaxel • doxorubicin hydrochloride • cyclophosphamide • seribantumab (MM-121)