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BIOMARKER:
ROS1 fusion
i
Other names:
ROS Proto-Oncogene 1 Receptor Tyrosine Kinase, V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1, C-Ros Oncogene 1 Receptor Tyrosine Kinase, Proto-Oncogene Tyrosine-Protein Kinase ROS, Proto-Oncogene C-Ros-1, MCF3, ROS, V-Ros UR2 Sarcoma Virus Oncogene Homolog 1 (Avian), ROS Proto-Oncogene 1 Receptor Tyrosine Kinase, Transmembrane Tyrosine-Specific Protein Kinase, Receptor Tyrosine Kinase C-Ros Oncogene 1, C-Ros Receptor Tyrosine Kinase, Proto-oncogene C-Ros, C-Ros-1
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Entrez ID:
6098
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
CD74-ROS1 F2004L + PD-L1 expression (3)
BRAF V600E + ROS1 fusion (2)
CD74-ROS1 fusion + MET D1228N + MET amplification (2)
CD74-ROS1 fusion + TMB-H (1)
CD74-ROS1 fusion + TP53 mutation (1)
EGFR L858R + ROS1 fusion (1)
EGFR L858R + ROS1-ADGRG6 fusion (1)
GOPC-ROS1 G2032 (1)
GOPC-ROS1 fusion + CTNNB1 S45F (1)
GOPC-ROS1 fusion + KRAS Q61H (1)
ROS1 fusion + KRAS G12C (1)
ROS1 fusion + NBN mutation (1)
ROS1 fusion + ROS1 G2032R (1)
ROS1 fusion + TP53 mutation (1)
ROS1 mutation + MSI-L/dMMR (1)
ROS1 positive + MET amplification (1)
ROS1 rearrangement + PD-L1 overexpression (1)
ROS1 rearrangement + ROS1 F2004L (1)
ROS1 translocation + EGFR wild-type (1)
ROS1-CD74 fusion + TP53 K139N (1)
TJP1-ROS1 fusion + NF1 mutation (1)
WNK1-ROS1 fusion + ROS1 G2032R (1)
CD74-ROS1 F2004L + PD-L1 expression (3)
BRAF V600E + ROS1 fusion (2)
CD74-ROS1 fusion + MET D1228N + MET amplification (2)
CD74-ROS1 fusion + TMB-H (1)
CD74-ROS1 fusion + TP53 mutation (1)
EGFR L858R + ROS1 fusion (1)
EGFR L858R + ROS1-ADGRG6 fusion (1)
GOPC-ROS1 G2032 (1)
GOPC-ROS1 fusion + CTNNB1 S45F (1)
GOPC-ROS1 fusion + KRAS Q61H (1)
ROS1 fusion + KRAS G12C (1)
ROS1 fusion + NBN mutation (1)
ROS1 fusion + ROS1 G2032R (1)
ROS1 fusion + TP53 mutation (1)
ROS1 mutation + MSI-L/dMMR (1)
ROS1 positive + MET amplification (1)
ROS1 rearrangement + PD-L1 overexpression (1)
ROS1 rearrangement + ROS1 F2004L (1)
ROS1 translocation + EGFR wild-type (1)
ROS1-CD74 fusion + TP53 K139N (1)
TJP1-ROS1 fusion + NF1 mutation (1)
WNK1-ROS1 fusion + ROS1 G2032R (1)
›
Related tests:
FoundationOne® CDx (110)
Oncomine™ Dx Target Test (10)
FoundationOne® CDx (110)
Oncomine™ Dx Target Test (10)
Associations
News
Trials
VERI cancer hierarchy
Reset Filters
ROS1 fusion
Non Small Cell Lung Cancer
ROS1 fusion
Non Small Cell Lung Cancer
entrectinib
Sensitive: A1 - Approval
entrectinib
Sensitive
:
A1
entrectinib
Sensitive: A1 - Approval
entrectinib
Sensitive
:
A1
ROS1 fusion
Non Small Cell Lung Cancer
ROS1 fusion
Non Small Cell Lung Cancer
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
ROS1 fusion
Melanoma
ROS1 fusion
Melanoma
entrectinib
Sensitive: A2 - Guideline
entrectinib
Sensitive
:
A2
entrectinib
Sensitive: A2 - Guideline
entrectinib
Sensitive
:
A2
ROS1 fusion
Melanoma
ROS1 fusion
Melanoma
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
crizotinib
Sensitive: A2 - Guideline
crizotinib
Sensitive
:
A2
ROS1 fusion
Non Small Cell Lung Cancer
ROS1 fusion
Non Small Cell Lung Cancer
AB-106
Sensitive: B - Late Trials
AB-106
Sensitive
:
B
AB-106
Sensitive: B - Late Trials
AB-106
Sensitive
:
B
ROS1 fusion
Solid Tumor
ROS1 fusion
Solid Tumor
entrectinib
Sensitive: C1 - Off-label
entrectinib
Sensitive
:
C1
entrectinib
Sensitive: C1 - Off-label
entrectinib
Sensitive
:
C1
ROS1 fusion
Non Small Cell Lung Cancer
ROS1 fusion
Non Small Cell Lung Cancer
repotrectinib
Sensitive: C2 – Inclusion Criteria
repotrectinib
Sensitive
:
C2
repotrectinib
Sensitive: C2 – Inclusion Criteria
repotrectinib
Sensitive
:
C2
ROS1 fusion
Non Small Cell Lung Cancer
ROS1 fusion
Non Small Cell Lung Cancer
U3-1402
Sensitive: C2 – Inclusion Criteria
U3-1402
Sensitive
:
C2
U3-1402
Sensitive: C2 – Inclusion Criteria
U3-1402
Sensitive
:
C2
ROS1 fusion
Lung Non-Squamous Non-Small Cell Cancer
ROS1 fusion
Lung Non-Squamous Non-Small Cell Cancer
bevacizumab + atezolizumab
Sensitive: C2 – Inclusion Criteria
bevacizumab + atezolizumab
Sensitive
:
C2
bevacizumab + atezolizumab
Sensitive: C2 – Inclusion Criteria
bevacizumab + atezolizumab
Sensitive
:
C2
ROS1 fusion
Non Small Cell Lung Cancer
ROS1 fusion
Non Small Cell Lung Cancer
ensartinib
Sensitive: C3 – Early Trials
ensartinib
Sensitive
:
C3
ensartinib
Sensitive: C3 – Early Trials
ensartinib
Sensitive
:
C3
ROS1 fusion
Non Small Cell Lung Cancer
ROS1 fusion
Non Small Cell Lung Cancer
durvalumab
Resistant: C3 – Early Trials
durvalumab
Resistant
:
C3
durvalumab
Resistant: C3 – Early Trials
durvalumab
Resistant
:
C3
ROS1 fusion
Non Small Cell Lung Cancer
ROS1 fusion
Non Small Cell Lung Cancer
envonalkib
Sensitive: C3 – Early Trials
envonalkib
Sensitive
:
C3
envonalkib
Sensitive: C3 – Early Trials
envonalkib
Sensitive
:
C3
ROS1 fusion
Non Small Cell Lung Cancer
ROS1 fusion
Non Small Cell Lung Cancer
SAF-189
Sensitive: C3 – Early Trials
SAF-189
Sensitive
:
C3
SAF-189
Sensitive: C3 – Early Trials
SAF-189
Sensitive
:
C3
ROS1 fusion
Lung Non-Squamous Non-Small Cell Cancer
ROS1 fusion
Lung Non-Squamous Non-Small Cell Cancer
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
ROS1 fusion
Non Small Cell Lung Cancer
ROS1 fusion
Non Small Cell Lung Cancer
bevacizumab + crizotinib
Sensitive: C4 – Case Studies
bevacizumab + crizotinib
Sensitive
:
C4
bevacizumab + crizotinib
Sensitive: C4 – Case Studies
bevacizumab + crizotinib
Sensitive
:
C4
ROS1 fusion
Glioblastoma
ROS1 fusion
Glioblastoma
lorlatinib
Sensitive: D – Preclinical
lorlatinib
Sensitive
:
D
lorlatinib
Sensitive: D – Preclinical
lorlatinib
Sensitive
:
D
ROS1 fusion
Solid Tumor
ROS1 fusion
Solid Tumor
SIM1803-1A
Sensitive: D – Preclinical
SIM1803-1A
Sensitive
:
D
SIM1803-1A
Sensitive: D – Preclinical
SIM1803-1A
Sensitive
:
D
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