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BIOMARKER:
RET rearrangement
i
Other names:
RET, Ret Proto-Oncogene, Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret, Cadherin-Related Family Member 16, Rearranged During Transfection, RET Receptor Tyrosine Kinase, Cadherin Family Member 12, Proto-Oncogene C-Ret, CDHF12, CDHR16, PTC, Ret Proto-Oncogene (Multiple Endocrine Neoplasia And Medullary Thyroid Carcinoma 1, Hirschsprung Disease), Multiple Endocrine Neoplasia And Medullary Thyroid Carcinoma 1, Hirschsprung Disease 1, RET-ELE1, HSCR1, MEN2A, MEN2B, RET51, MTC1
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Entrez ID:
5979
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
KIF5B-RET fusion + RET G810C (3)
EGFR mutation + RET fusion (2)
KIF5B-RET fusion + RET G810S (2)
CCDC6-RET fusion + EGFR mutation (1)
CCDC6‐RET fusion + TERT promotor mutation (1)
GPRC6A-RET fusion + EGFR mutation (1)
KIF5B-RET fusion + EGFR exon 19 deletion (1)
KIF5B-RET fusion + MET amplification (1)
KIF5B-RET fusion + RET E732K (1)
KIF5B-RET fusion + RET L730I (1)
KIF5B-RET fusion + RET L730V (1)
KIF5B-RET fusion + RET M918T (1)
KIF5B-RET fusion + RET V804E (1)
KIF5B-RET fusion + RET V804M (1)
KIF5B-RET fusion + TP53 H193R + MYC amplification (1)
MET amplification + RET fusion (1)
PD-L1 overexpression + RET-CCDC6 fusion (1)
PD-L1 overexpression + RET-KIF5B fusion (1)
PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)
RET G810C + CCDC6-RET fusion (1)
RET amplification + TMB-H + PD-L1 expression (1)
RET positive + KRAS G12V (1)
RET positive + SMARCA4 mutation (1)
RET-MIR4299-MIR8070 fusion + RET amplification (1)
SHTN1-RET fusion + EGFR mutation (1)
SPECC1-RET fusion + EGFR mutation (1)
TLN1-RET fusion + EGFR mutation (1)
TRIM24-RET fusion + EGFR mutation (1)
TRIM33-RET fusion + EGFR mutation (1)
KIF5B-RET fusion + RET G810C (3)
EGFR mutation + RET fusion (2)
KIF5B-RET fusion + RET G810S (2)
CCDC6-RET fusion + EGFR mutation (1)
CCDC6‐RET fusion + TERT promotor mutation (1)
GPRC6A-RET fusion + EGFR mutation (1)
KIF5B-RET fusion + EGFR exon 19 deletion (1)
KIF5B-RET fusion + MET amplification (1)
KIF5B-RET fusion + RET E732K (1)
KIF5B-RET fusion + RET L730I (1)
KIF5B-RET fusion + RET L730V (1)
KIF5B-RET fusion + RET M918T (1)
KIF5B-RET fusion + RET V804E (1)
KIF5B-RET fusion + RET V804M (1)
KIF5B-RET fusion + TP53 H193R + MYC amplification (1)
MET amplification + RET fusion (1)
PD-L1 overexpression + RET-CCDC6 fusion (1)
PD-L1 overexpression + RET-KIF5B fusion (1)
PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)
RET G810C + CCDC6-RET fusion (1)
RET amplification + TMB-H + PD-L1 expression (1)
RET positive + KRAS G12V (1)
RET positive + SMARCA4 mutation (1)
RET-MIR4299-MIR8070 fusion + RET amplification (1)
SHTN1-RET fusion + EGFR mutation (1)
SPECC1-RET fusion + EGFR mutation (1)
TLN1-RET fusion + EGFR mutation (1)
TRIM24-RET fusion + EGFR mutation (1)
TRIM33-RET fusion + EGFR mutation (1)
›
Associations
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VERI cancer hierarchy
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RET rearrangement
Non Small Cell Lung Cancer
RET rearrangement
Non Small Cell Lung Cancer
cabozantinib tablet
Sensitive: A2 - Guideline
cabozantinib tablet
Sensitive
:
A2
cabozantinib tablet
Sensitive: A2 - Guideline
cabozantinib tablet
Sensitive
:
A2
RET rearrangement
Non Small Cell Lung Cancer
RET rearrangement
Non Small Cell Lung Cancer
selpercatinib
Sensitive: A2 - Guideline
selpercatinib
Sensitive
:
A2
selpercatinib
Sensitive: A2 - Guideline
selpercatinib
Sensitive
:
A2
RET rearrangement
Non Small Cell Lung Cancer
RET rearrangement
Non Small Cell Lung Cancer
pralsetinib
Sensitive: A2 - Guideline
pralsetinib
Sensitive
:
A2
pralsetinib
Sensitive: A2 - Guideline
pralsetinib
Sensitive
:
A2
RET rearrangement
Non Small Cell Lung Cancer
RET rearrangement
Non Small Cell Lung Cancer
alectinib
Sensitive: C2 – Inclusion Criteria
alectinib
Sensitive
:
C2
alectinib
Sensitive: C2 – Inclusion Criteria
alectinib
Sensitive
:
C2
RET rearrangement
Non Small Cell Lung Cancer
RET rearrangement
Non Small Cell Lung Cancer
sunitinib
Sensitive: C2 – Inclusion Criteria
sunitinib
Sensitive
:
C2
sunitinib
Sensitive: C2 – Inclusion Criteria
sunitinib
Sensitive
:
C2
RET rearrangement
Non Small Cell Lung Cancer
RET rearrangement
Non Small Cell Lung Cancer
vandetanib
Sensitive: C3 – Early Trials
vandetanib
Sensitive
:
C3
vandetanib
Sensitive: C3 – Early Trials
vandetanib
Sensitive
:
C3
RET rearrangement
Non Small Cell Lung Cancer
RET rearrangement
Non Small Cell Lung Cancer
selpercatinib + pralsetinib
Sensitive: C3 – Early Trials
selpercatinib + pralsetinib
Sensitive
:
C3
selpercatinib + pralsetinib
Sensitive: C3 – Early Trials
selpercatinib + pralsetinib
Sensitive
:
C3
RET rearrangement
Lung Adenocarcinoma
RET rearrangement
Lung Adenocarcinoma
cabozantinib tablet
Sensitive: C3 – Early Trials
cabozantinib tablet
Sensitive
:
C3
cabozantinib tablet
Sensitive: C3 – Early Trials
cabozantinib tablet
Sensitive
:
C3
RET rearrangement
Thyroid Gland Carcinoma
RET rearrangement
Thyroid Gland Carcinoma
selumetinib
Sensitive: D – Preclinical
selumetinib
Sensitive
:
D
selumetinib
Sensitive: D – Preclinical
selumetinib
Sensitive
:
D
RET rearrangement
Thyroid Gland Papillary Carcinoma
RET rearrangement
Thyroid Gland Papillary Carcinoma
MK-2206
Sensitive: D – Preclinical
MK-2206
Sensitive
:
D
MK-2206
Sensitive: D – Preclinical
MK-2206
Sensitive
:
D
RET rearrangement
Thyroid Gland Carcinoma
RET rearrangement
Thyroid Gland Carcinoma
AZD1480
Sensitive: D – Preclinical
AZD1480
Sensitive
:
D
AZD1480
Sensitive: D – Preclinical
AZD1480
Sensitive
:
D
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